董波

发布者:刘明港发布时间:2020-06-26浏览次数:147

董波 教授 博士生导师

海洋生物多样性与进化研究所副所长

山东省泰山学者海外特聘专家

中国海洋大学筑峰工程特聘教授

E-mail: bodong@ouc.edu.cn

Tel: 0532-82032732

https://www.researchgate.net/profile/Bo_Dong4


教育及工作背景:1997年毕业于青岛海洋大学,2005年在中国科学院海洋研究所获博士学位,2006-2010年在挪威卑尔根大学萨斯国际海洋分子生物学中心做博士后, 2010-2014年受聘任日本理化学研究所神户发育生物学中心国际特别研究员。2014年至今任中国海洋大学“筑峰计划”特聘教授、青岛市创新创业领军人才、山东省“泰山学者”特聘教授、山东省有突出贡献中青年专家。现任中国海洋湖沼学会理事,《Marine Life Science & Technology》和《中国海洋大学学报》(自然科学版)等期刊编委。主持科技部重点研发计划政府间重点专项、国家基金和山东省重大研发等多个项目。


主要研究方向及成果:

主要从事动物遗传发育生物学研究,以进化节点动物海鞘和模式动物果蝇为实验材料,通过遗传学、细胞发育生物学和生物物理学等多学科交叉途径,研究囊泡极性运输、细胞骨架动态、胞外基质物理特性及其对细胞行为的影响等。在器官发育和稳态维持机制等方面取得重要进展,发现了脊索管腔形成的细胞学过程,揭示了调控细胞及器官形态发育变化的重要信号通路,建立了决定生物管腔几何形状的数学物理模型。研究成果发表在PNAS, PLoS Biology, eLife, Nature CommunicationsCell ReportsDevelopmentFASEB J等领域主流刊物。


实验室目前有硕士、博士及博士后位置开放,并欢迎客座研究科学家交流合作。如果您对实验室研究领域和方向感兴趣,并具有发育生物学、细胞生物学或生物物理学等背景,欢迎来信询问。


Prof. Dr. Bo DONG:

2014.9-: Professor, Ocean University of China, Qingdao, China;

2013.11- 2014. 9: Research Scientist, RIKEN Center for Developmental Biology (CDB), Kobe, Japan;

2010.11- 2013.10: Foreign Postdoctoral Researcher, RIKEN CDB;

2006.10- 2010.10: Postdoctoral fellow, Sars International Centre for Marine Molecular Biology, Bergen, Norway;

2001.7- 2005.7: Ph.D., Institute of Oceanology, Chinese Academy of Sciences (IOCAS), Qingdao, China.


Research Interests:

Our group is principally interested in uncovering cellular processes and the underlying mechanisms that support the biological tube formation. We use marine animal (Ciona) notochord andDrosophila tracheal system as models to understand the morphogenetic signaling network on polarized vesicle trafficking, cytoskeletal organization, membrane biogenesis and extracellular matrix dynamics during lumen formation and cell shape change.


Job and Contact: 

We are always looking for people with experience and interests in developmental biology, Cell biology or biophysics to join us. If you are interested in working with us as a graduate student, postdoc or visiting scientist, please contacts us for possible openings.

Laboratory for Molecular Mechanisms and Cellular Biophysics of Organogenesis

Institute of Evolution & Marine Biodiversity, Ocean University of China

No.5 Yushan Road, 266003, Qingdao, China

Tel: 0532-82032732

E-mail:bodong@ouc.edu.cn


代表性文章 *通讯作者,#共同第一作者

Bhattachan P., Rae J, Yu H, Jung W., Wei J.,Parton R. G., and Dong B*, Ascidian caveolin induces membrane curvature and protects tissue integrity and morphology during embryogenesis. The FASEB Journal, 2020, 34 (1): 1345-1361.

Lv Z, Lu Q, Dong B*, Morphogenesis: a focus on marine invertebrates. Marine Life Science & Technology, 2019, 1: 28-40.

Lu Q, Bhattachan P, Dong B*. Ascidian notochord elongation, Developmental Biology. 2019, 448147-153.

Zhang X, Liu X, Liu C, Wei J, Yu H, Dong B*. Identification and characterization of microRNAs involved in ascidian larval metamorphosis. BMC Genomics. 2018, 19(1):168

Wei J, Wang G, Li X, Ren P, Yu H, Dong B*. 2017. Architectural delineation and molecular identification of extracellular matrix in ascidian embryos and larvae. Biology Open 6(9): 1383-1390. (封面文章)

董波*。海洋模式动物海鞘及其脊索发育与调控科学通报, 201560: 1167-1179.

Sehring I, Recho P, Denker E, Kourakis M, Mathiesen B, Hannezo E*, Dong B*, Jiang D*. 2015. Assembly and positioning of actomyosin rings by contractility and planar cell polarity.eLife 4: e09206. (当期亮点文章,faculty of 1000专家推荐)

Hannezo E#, *, Dong B#, *, Recho P, Joanny JF, Hayashi S. 2015. A cortical instability drives periodic supracellular actin pattern formation in epithelial tubes. PNAS 112 (28): 8620-8625. (PNAS同期配发了点评文章)

Dong B, Hayashi S. Shaping of biological tubes by mechanical interaction of cell and extracellular matrix. Current Opinion in Genetics & Development, 2015, 32: 129-134.(邀请综述文章)

Sehring I#,Dong B#,Denker E,Bhattachan P,Deng W, Mathiesen B, Jiang D. An equatorial contractile mechanism drives cell elongation but not cell division. PLoS Biology, 2014,12(2): e1001781. (同期配发了点评文章faculty of 1000专家推荐)

Dong B*, Hannezo E, Hayashi S*. 2014. Balance between apical membrane growth and luminal matrix resistance determines the shape of epithelial tubule. Cell Reports 7(4): 941-950.

Dong B, Miao GX, Hayashi S. A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis in Drosophila. Development, 2014 141 (21): 4104-4109. (当期亮点文章)

DongB, KakiharaK, Otani T, WadaH, Hayashi S. 2013. Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control. Nature Communications 4, 1358.

Dong B, Deng W, Jiang D, Distinct cytoskeleton populations and extensive crosstalk control Ciona notochord tubulogenesis. Development, 2011, 138 (8): 1631-1641.(faculty of 1000专家推荐)

Dong B, Horie T, Denker E, Kusakabe T, Tsuda M, Smith WC, Jiang D.  Tube formation by complex cellular processes in Ciona intestinalis notochord. Developmental Biology, 2009. 330: 237-249.