• 研究方向


           实验室的研究方向是动物组织器官形态发生与适应性进化。以果蝇和海鞘等模式动物为材料,通过细胞遗传发育生物学技术手段,结合数学物理模型,研究囊泡极性运输、细胞骨架动态、细胞外基质物理特性在动物重要器官形成过程中的角色和功能。同时运用组学途径揭示海鞘环境适应的基因组学基础及肠道微生物同宿主间的协同进化。在器官发育和稳态维持机制等方面取得重要进展,发现了脊索管腔形成的细胞学过程,揭示了调控细胞及器官形态发育变化的重要信号通路,建立了决定生物管腔几何形状的数学物理模型。研究成果发表在PNAS, PLoS Biology, eLife, Nature CommunicationsCell ReportsDevelopmentFASEB J等领域主流刊物。



  • 承担课题


    · 国家重点研发计划政府间国际科技创新合作重点专项:细胞外基质在管腔器官形态发生与稳态维持中的角色和功能研究 (2020-2023)  

    · 国家基金面上项目:真海鞘肠道微生物组学解析及活性成分功能鉴定 (2020-2023)

    · 国家基金面上项目:软骨调节素在海鞘脊索腔液形成中的分子调控机制(2018-2021)

    · 国家基金面上项目:小窝蛋白在海洋模式动物海鞘脊索发育中的角色(2016-2019)

    · 国家基金青年项目:激活T细胞核因子5在海鞘脊索管腔形成中的渗透调控机制(2017-2019)

    · 国家基金青年项目:间充质细胞miR-4018a调控海鞘幼体变态的作用机制(2018-2020)

    · 山东省重大科技创新工程专项课题海洋微生物基因组进化及其与宿主协同进化(2018-2020)

    · 山东省重大科技创新工程专项课题:海洋动物个体发育与系统演化遗传基础(2018-2020)


  • 近期论文及成果


    *通讯作者,#共同第一作者)

    1. Wei J, Zhang J, Lu Q, Ren P, Guo X, Wang J, Li X, Chang Y, Duan S, Wang S, Yu H, Zhang X, Yang X, Gao H, Dong B*, Genomic basis of environmental adaptation in the leathery sea squirt (Styela clava). Molecular Ecology Resources. 2020.https://doi.org/10.1111/1755-0998.13209.(被选为亮点文章)

    2. Wei J, Gao H, Yang Y, Liu H, Yu H, Chen Z*, Dong B*, Seasonal dynamics and starvation Impact on the gut microbiome of urochordate ascidian Halocynthia roretz. Animal Microbiome, 2020, 2: 30. https://doi.org/10.1186/s42523-020-00048-2.

    3. Bhattachan P, Rae J, Yu H, Jung W, Wei J, Parton R. G, and Dong B*, Ascidian caveolin induces membrane curvature and protects tissue integrity and morphology during embryogenesis. The FASEB Journal, 2020, 34 (1): 1345-1361.

    4. Lv Z, Lu Q, Dong B*, Morphogenesis: a focus on marine invertebrates. Marine Life Science & Technology, 2019, 1: 28-40.

    5. Lu Q, Bhattachan P, Dong B*. Ascidian notochord elongation, Developmental Biology. 2019, 448147-153.

    6. Zhang X, Liu X, Liu C, Wei J, Yu H, Dong B*. Identification and characterization of microRNAs involved in ascidian larval metamorphosis. BMC Genomics. 2018, 19(1):168

    7. Wei J, Wang G, Li X, Ren P, Yu H, Dong B*. 2017. Architectural delineation and molecular identification of extracellular matrix in ascidian embryos and larvae. Biology Open 6(9): 1383-1390. (封面文章)

    8. 董波*。海洋模式动物海鞘及其脊索发育与调控科学通报, 201560: 1167-1179.

    9. Sehring I, Recho P, Denker E, Kourakis M, Mathiesen B, Hannezo E*, Dong B*, Jiang D*. 2015. Assembly and positioning of actomyosin rings by contractility and planar cell polarity.eLife 4: e09206. (当期亮点文章,faculty of 1000专家推荐)

    10. Hannezo E#, *, Dong B#, *, Recho P, Joanny JF, Hayashi S. 2015. A cortical instability drives periodic supracellular actin pattern formation in epithelial tubes. PNAS 112 (28): 8620-8625. (PNAS同期配发了点评文章)

    11. Dong B, Hayashi S. Shaping of biological tubes by mechanical interaction of cell and extracellular matrix. Current Opinion in Genetics & Development, 2015, 32: 129-134.(邀请综述文章)

    12. Sehring I#,Dong B#,Denker E,Bhattachan P,Deng W, Mathiesen B, Jiang D. An equatorial contractile mechanism drives cell elongation but not cell division. PLoS Biology, 2014,12(2): e1001781. (同期配发了点评文章faculty of 1000专家推荐)

    13. Dong B*, Hannezo E, Hayashi S*. 2014. Balance between apical membrane growth and luminal matrix resistance determines the shape of epithelial tubule. Cell Reports 7(4): 941-950.

    14. Dong B, Miao GX, Hayashi S. A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis in Drosophila. Development, 2014 141 (21): 4104-4109. (当期亮点文章)

    15. DongB, KakiharaK, Otani T, WadaH, Hayashi S. 2013. Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control. Nature Communications 4, 1358.

    16. Dong B, Deng W, Jiang D, Distinct cytoskeleton populations and extensive crosstalk control Ciona notochord tubulogenesis. Development, 2011, 138 (8): 1631-1641.(faculty of 1000专家推荐)

    17. Dong B, Horie T, Denker E, Kusakabe T, Tsuda M, Smith WC, Jiang D.  Tube formation by complex cellular processes in Ciona intestinalis notochord. Developmental Biology, 2009. 330: 237-249.