• 研究方向


    海洋药物化学与药生物学。围绕海洋药用生物资源,开展海洋药用生物多样性、代谢及其调控,海洋天然产物化学及其生物学功能,海洋药物先导化合物发现与优化研究。重点开展典型海洋环境中药用生物 (海洋无脊椎动物微生物) 活性次级代谢产物研究,针对癌症、感染性疾病、神经退行性疾病等严重威胁人类健康的重大疾病,筛选发现活性海洋天然产物,通过设计、优化、合成靶向性发现药物先导化合物。


     海洋天然产物挖掘及其作用机制


  • 承担课题


    · 国家海洋“863”主题项目1项(首席专家)

    · 国家自然科学基金重点项目1项,优秀青年基金1项,面上项目5项

    · 国家海洋局海洋公益性行业科研专项1项


  • 近期论文及成果


    1. Lu Liu, Zheng Zhang*, Chang-Lun Shao, Jin-Lan Wang, Hong Bai, Chang-Yun Wang*. Bioinformatical analysis of the      sequences, structures and functions of fungal polyketide synthase product template domains. Sci. Rep., 2015, 5(10463): 1−12.

    2.  Dong-Lin Zhao, Chang-Lun Shao, Li-She Gan, Mei Wang, Chang-Yun Wang*. Chromone derivatives from a sponge-derived strain of the fungus Corynespora cassiicolaJ. Nat. Prod., 2015, 78, 286−293.

    3. Xiao-Yan Qin, Kai-Lin Yang, Jing Li, Chang-Yun Wang*, Chang-Lun Shao*. Phylogenetic diversity and antibacterial activity of culturable fungi derived from the Zoanthid Palythoa haddoni in the South China Sea. Mar. Biotech., 2015, 17(1): 99-109

    4. Chang-Lun Shao*, Ru-Fang Xu, Chang-Yun Wang, Pei-Yuan Qian, Kai-Ling Wang, Mei-Yan Wei. Potent antifouling marine dihydroquinolin-2(1H)-one-containing alkaloids from the gorgonian coral-derived fungus Scopulariopsis sp.. Mar. Biotech., 2015, 17: 408–415.

    5. Fei Cao, Ze-Hong Wu, Chang-Lun Shao, Sen Pang, Xiao-Yan Liang, Nicole J. de Voogd, Chang-Yun Wang*. Cytotoxic scalarane sesterterpenoids from the South China Sea sponge Carteriospongia foliascensOrg. Biomol. Chem., 2015, 13, 4016−4024.

    6. Qing-Ai Liu, Chang-Lun Shao, Yu-Cheng Gu, Mathias Blum, Li-She Gan, Kai-Ling Wang, Min Chen, Chang-Yun Wang*. Antifouling and fungicidal resorcylic acid lactones from the sea anemone-derived fungus Cochliobolus lunatus.J. Agric. Food Chem., 2014, 62: 3183−3191.

    7. Fei Cao, Chang-Lun Shao, Min Chen, Meng-Qi Zhang, Kai-Xia Xu, Hong Meng,* Chang-Yun Wang*. Antiviral C-25 epimers of 26-acetoxy steroids from the South China Sea gorgonian Echinogorgia rebekkaJ. Nat. Prod., 2014, 77, 1488−1493.

    8. Min Chen, Chang-Lun Shao, Xiu-Mei Fu, Chui-Jian Kong, Zhi-Gang She, Chang-Yun Wang*. Lumazine peptides penilumamides B–D and the cyclic pentapeptide asperpeptide A from a gorgonian-derived Aspergillus sp. fungus. J. Nat. Prod., 2014, 77: 1601–1606.

    9. Min Chen, Chang-Lun Shao, Hong Meng, Zhi-Gang She, Chang-Yun Wang*. Anti-respiratory syncytial virus prenylated dihydroquinolone derivatives from the gorgonian-derived fungus Aspergillus sp. XS-20090B15. J. Nat. Prod., 2014, 77, 2720−2724.

    10. Chang-Lun Shao, Ru-Fang Xu, Mei-Yan Wei, Zhigang She*, Chang-Yun Wang*. Structure and absolute configuration of fumiquinazoline L, an alkaloid from a gorgonian-derived Scopulariopsis sp. fungus. J. Nat. Prod., 2013, 76, 779−782. 


  • 其他

    主编和参编专著10部;获授权国家发明专利8项;获山东省科技进步二等奖1项。