• 研究方向


    纤毛普遍存在于高等动物细胞内,在胚胎发育过程中发挥重要生物学功能。纤毛发育异常可引起眼睛、肾脏等多个器官的病变,是导致多种人类遗传疾病形成的重要原因。本课题组致力于研究纤毛发育的分子基础,以斑马鱼、丝盘虫以及纤毛虫等为模式动物,结合分子生物学,遗传学及生物化学等多种手段解析纤毛发育的分子机制,通过构建多种疾病的动物模型研究其致病机理,为最终纤毛疾病的治疗打下基础。课题组的主要研究方向包括:1)体轴发育的调控机制;2)感光细胞的发育及凋亡机理;3)纤毛病基因的致病机制;4)纤毛的发生与进化机制。课题组目前跟国内外多个高校及医院建立了密切合作关系,在纤毛病发病机制的研究方面取得了重要进展,研究成果先后发表在Nature Genetics, PNAS, EMBO Journal, PLOS Genetics等国际前沿刊物上。

    Cilia exist in many phyla from protozoa to mammalian cells and play diverse biological functions. Disruption in cilia function has been linked to many human genetic disorders, collectively termed as ciliopathies. Our lab is interested in the study of mechanisms underlying ciliogenesis using multiple organisms, including zebrafish, placozoa and ciliates. Currently, the main focus of our lab include: 1) The mechanisms of body axis development regulated by cilia-driven cerebrospinal fluid; 2) Degeneration and renewal of photoreceptor cells; 3) Role of cilia and ciliary genes in ciliopathies; 4) Functional evolution of cilia. Our recent findings have been published in several high impact journals including Nature Genetics, PNAS, EMBO Journal and PLOS Genetics.


         

  • 承担课题



    · 国家自然科学基金委重大项目

    · 国家自然科学基金委杰出青年基金项目

    · 国家自然科学基金委优秀青年科学基金

    · 山东省泰山学者支持经费

    · 山东省杰出青年基金项目

    · 教育部新世纪优秀人才项目

    · 中国海洋大学筑峰人才工程启动经费

    · 海洋科学国家实验室鳌山人才青年学者项目


  • 近期论文及成果


    1. 1. Zhao L#, Xie H#, Kang Y, Lin Y, Liu G, Sakato-Antoku M, Patel-King RS, Wang B, Wan C, King SM, Zhao C*, Huang K*. Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating. PNAS. 2021 ;118(17):e2015689118. 

    2. 2. Luo M#, Lin Z#, Zhu T#, Jin M#, Meng D, He R, Cao Z, Shen Y, Lu C, Cai R, Zhao Y, Wang X, Li H, Wu S, Zou X, Luo G, Cao L, Huang M, Jiao H, Gao H, Sui R*, Zhao C*, Ma X*, Cao M*. Disrupted intraflagellar transport due to IFT74 variants causes Joubert syndrome. Genet Med. 2021  doi: 10.1038/s41436-021-01106-z.

    3. 3. Wang X#, Wang S#, Meng Z, Zhao C. Adrb1 and Adrb2b are the major β-adrenergic receptors regulating body axis straightening in zebrafish. J Genet Genomics. 2020

    4. 4. Xie H#, Kang Y#, Wang S, Zheng P, Chen Z, Roy S,  Zhao C. E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLOS Genetics, 2020 16 (3), e1008655. 

    5. 5. Zhang X#, Jia S#, Chen Z, Chong YL, Xie H, Feng D, Wu X, Song DZ, Roy S, Zhao C. Cilia-driven cerebrospinal fluid flow directs expression of Urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 2018 50(12):1666-1673. 

    6. 6. Han X#, Xie H#, Wang Y, Zhao C. Radial spoke proteins regulate otolith formation during early zebrafish development. FASEB J. 2018 32(7):3984-3992. 

    7. 7. Feng D, Chen Z, Yang K, Miao S, Xu B, Kang Y, Xie H, Zhao C. The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants. J Bio Chem.  2017;292(42):17375-17386.

    8. 8. Song Z, Zhang X, Jia S, Yelick PC, Zhao C.  Zebrafish as a Model for Human Ciliopathies. J Genet Genomics. 2016 20;43(3):107-20. 

    9. 9. Zhao C*, Andreeva V, Gibert Y, LaBonty M, Lattanzi V, Prabhudesai S, Zhou Y, Zon L, McCann KL, Baserga S, Yelick PC*. Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS Genet. 2014, 10(1):e1004074 

    10. 10. Zhao C, Omori Y, Brodowska K, Kovach P, Malicki J: Kinesin-2 family in vertebrate ciliogenesis. PNAS, 2012 109(7):2388-93.

    11. 11. Zhao C, Malicki J. Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. EMBO J. 2011;30(13):2532-44.

    12. 12. Omori Y, Zhao C, Saras A, Mukhopadhyay S, Kim W, Furukawa T, Sengupta P, Veraksa A, Malicki J. Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8. Nat Cell Biol. 2008 10(4):437-44.