进化基因组学实验室
Laboratory of Evolutionary Genomics
P.I.: Prof. Hongan LONG


育人为本,创新领先





  • 研究方向


          利用组学、分子遗传学和细胞生物学方法,结合种群遗传学与微生物学理论,聚焦生物的基因组突变以及生活史的进化生物学研究,具体研究方向如下:

    A. 表型可塑性与适应性演化;

    B. 基因组进化以及稳定性机制;

    C. 环境胁迫下的突变形成;

    D. 医疗及环境水体中病原微生物的抗药性演化;

    E. 原生动物生殖方式的调控与演化。  


          We are interested in microbial evolution, with a focus on mutation rate and behavior evolution. The research models are quite broad, including cilaites, bacteria, yeast, etc. Our research strategy combines population genetics theory, experimental evolution, -omics sequencing, genetic techniques, and bioinformatic tools. The lab deems the training of indepedent researchers as our first task and research as the second. Graduate students would get a complete training of scientific research and multiple undergrad assistants are provided for their research. We are now exploring the following topics:

    A. Phenotypic plasticity of ciliates, and its role in evolution;

    B. Genome instability and evolution of marine microbial organisms;

    C. Ecological dependence of mutation rate;

    D. Antibiotic resistance evolution of pathogens in medical and natural environments;

    E. Genetic regulation and evolution of reproduction in ciliates.


  • 招聘/招生


    招聘:协助拟加入人员申请中国海洋大学“青年英才工程”(http://rsc.ouc.edu.cn/04/50/c1485a66640/page.htm)等各层次人才计划;定期招收实验室管理、技术等科研助理岗位。

    招生:常年招收优秀本科生兼职助理、硕士生、博士生和博士后。

    具体信息请邮件咨询(longhongan@ouc.edu.cn)


  • 实验室负责人


    P.I.  

    龙红岸  授  博士生导师

    1982年8月出生 

    Hongan Long, Professor, Ph.D.

    E-mail: longhongan@ouc.edu.cn

    Tel: +86 532 8203 1723

    简历 Resume



  • 承担课题


    • 第15批国家“青千”(2019-2021)

    • 山东省“泰山学者”青年项目(2019.1-2024.1)

    • 国家自然科学基金国际(地区)合作项目(31961123002; 2019.10-2024.9)

    • 国家自然科学基金面上项目(31872228; 2019.1-2022.12)

    • 中央高校基本科研业务费(2018.1-2021.1)

    • 中国海洋大学“筑峰人才计划”启动经费(2018.9-2021.8)

    • Taishan Scholar' grant for young scientists, Shandong Province (2019.1-2024.1)

    • NSFC grants (No.31872228, 2019.1-2022.12, Phenotypic plasticity and its evolution in the ciliate Glauconema trihymene; No. 31961123002, 2019.10-2024.9, Global patterns of biodiversity in the ancient ciliate Paramecium)

    • Research grant from the Central Government of China (2018.1-2021.1)

    • Startup grant from Ocean University of China (2018.9-2021.8)


  • 近期论文及成果


    *,corresponding author; #, co-first-author

    Recent publications

    Full texts of publications can be downloaded from researchgate

    1. Nguyen, D.; Wu, B.; Long*, H.; Zhang, N.; Patterson, C.; Simpson, S.; Morris, K.; Thomas, W.; Lynch, M.; Hao*, W. 2020. Variable spontaneous muation and loss of heterozygosity among heterozygous genomes in yeast. Molecular Biology and Evolution In Press.

    2. Pan, J.; Williams, E.; Sung, W.; Lynch, M.; Long*, H. 2020. The insect-killing bacterium Photorhabdus luminescens has the lowest mutation rate among bacteria. Marine Life Science and Technology In Press.

    3. Li, Y.; Chen, X.; Wu, K.; Pan, J.; Long*, H.; Yan*, Y. 2020. Characterization of simple sequence repeats (SSRs) in ciliated protists inferred by comparative genomics. Microorganisms 8(5): 662.

    4. Li, H.; Wu, K.; Ruan, C.; Pan, J.; Wang, Y.; Long*, H. 2019. Cost-reduction strategies in massive genomics experiments. Marine Life Science and Technology 1: 15-21. 

    5. Long*, H.; Miller, S.F.; Williams, E.; Lynch, M. 2018. Specificity of the DNA mismatch repair system (MMR) and mutagenesis bias in bacteria. Molecular Biology and Evolution 35(10):2414–2421.    

    6. Long, H.; Sung#, W.; Kucukyildirim#,S.; Williams,E.; Miller, S.;Guo, W.; Patterson, C.; Gregory, C.; Strauss, C.; Stone, C.; Berne, C.; Kysela, D.; Shoemaker, W.; Muscarella, M.; Luo, H.; Lennon, J.; Brun, Y.; Lynch*, M. 2018. Evolutionary determinants of genome-wide nucleotide composition. Nature Ecology and Evolution 2: 237-240.  

    7. Strauss, C.; Long*, H.; Patterson, C.; Te, R.; Lynch, M. 2017. Genome-wide mutation rate response to pH change in the coral reef pathogen Vibrio shilonii AK1. mBio 8 (4): e01021-17  

    8. Long, H.; Miller, S.F.; Strauss, C.; Zhao, C.; Cheng, L.; Ye, Z.; Griffin, K.; Te, R.; Lee, H.; Chen, C.; Lynch*, M. 2016. Antibiotic treatment enhances the genome-wide mutation rate of target cells. Proceedings of the National Academy of Sciences U.S.A. 113(18): E2498-E2505  

    9. Long*, H.; Kucukyildirim#, S.; Sung, W.; Williams, E.; Lee, H.; Ackerman, M.; Doak, T.; Tang, H.; Lynch, M. 2015. Background mutational features of the radiation-resistant bacterium Deinococcus radioduransMolecular Biology and Evolution 32(9): 2383-2392 

    10. Long*, H.; Sung, W.; Miller, S.F.; Ackerman, M.; Doak, T.; Lynch, M. 2015. Mutation rate, spectrum, topology, and context-dependency in the DNA mismatch repair-deficient Pseudomonas fluorescens ATCC948. Genome Biology and Evolution 7(1): 262-271 

    11. Farlow*, A.; Long#, H.; Arnoux, S.; Sung, W.; Doak, T.; Nordborg, M.; Lynch, M. 2015. The spontaneous mutation rate in the fission yeast Schizosaccharomyces pombeGenetics 201(2):737-744 

    12. Long*, H.; Paixão, T.; Azevedo, R.; Zufall, R. 2013. Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophilaGenetics 195(2): 527-540 

    13. Long*, H.; Zufall, R.A. 2010. Diverse modes of reproduction in the marine free-living ciliate Glauconema trihymeneBMC Microbiology 10(1): 108


  • 奖项

    2019 中国海洋大学第21届天泰奖一等奖;中国海洋大学优秀班主任

    2018 李氏基金会杰出创新奖

    2016 美国遗传学会DeLill Nasser遗传学职业发展奖

    2018 Li Foundation Heritage Prize-Excellence in Creativity

    2016 DeLill Nasser Award for Professional Development in Genetics, Genetics Society of America


  • 实验室人员


    People in the lab


    研究生:

    吴琨(2019级博士研究生),水生生物学,wukun@stu.ouc.edu.cn,细菌基因组的自发与诱导突变

    潘娇(2019级博士研究生),水生生物学,panjiao@stu.ouc.edu.cn,微生物的突变与表型可塑性

    蒋婉月(2020级博士研究生),水生生物学,jiangwanyue@stu.ouc.edu.cn,稀有突变的探测与原位突变率

    李海潮(2020级博士研究生),水生生物学,lihaichao@stu.ouc.edu.cn,纤毛虫原生动物的基因组演化

    林彤彤(2019级硕士研究生),生物学,lintongtong@stu.ouc.edu.cn,微生物基因组的极端演化

    倪家豪(2019级硕士研究生),生物工程,nijiahao@stu.ouc.edu.cn,纤毛虫多样性的产生与维持

    Pish Wattandilokchatkun (2019级硕士研究生,泰国留学生),水产养殖,pish.wtk@gmail.com,水产微生物基因组学

    周霞(2020级硕士研究生),水生生物学,zhouxia@stu.ouc.edu.cn,抗生素诱导突变

    郭慧琳(2020级硕士研究生),水生生物学,guohuilin@stu.ouc.edu.cn,种间作用影响下的基因组演化

    本科生:

    2017级:邓子光(生物科学)、兰烨琳(海洋渔业)、王瑶海(水产养殖)、张渊渊(海洋渔业)

    2018级:韩玉敏(水产养殖)、邱文燕(水产养殖)、迟润达(水产养殖)、冯若冰(生物技术)、刘明港(水产养殖)、姚栋基(生态)、黄维(水产养殖)、陈宁(水产养殖)、冉大鹏(水产养殖)、程方(水产养殖)、柯珅(水产养殖)、黄伟健(水产养殖)、李荟(生态)、石润芝(水产养殖)、包汉静(生态)、牛泽华(生态)、靳元江(水产养殖)、陈俊昊(水产养殖)、常中宇(水产养殖)、陈祺凯(水产养殖)、陈为哲(生态)、蔡雨君(生物技术)、高佳倩(水产养殖)

    2019级:高超(生物科学)、曹吉超(生物科学)、段云轩(生物科学)



  • 其他


    业余创作教育题材小说《转变 第一部》:

    链接:https://pan.baidu.com/s/1PTtD1JZBWlVapdHXC50Rgg 

    提取码:e0qv