进化基因组学实验室
Laboratory of Evolutionary Genomics
P.I.: Prof. Hongan LONG


育人为本,创新领先





  • 研究方向

    利用组学、遗传学和微生物学方法,以纤毛虫原生动物、细菌、酵母等为研究模式,研究生物多样性的产生与演变机制,聚焦微生物的突变规律和生活史演化,具体研究主题如下:

    A. 表型可塑性与适应性演化

    B. 基因组演化以及稳定性机制

    C. 环境胁迫下的突变形成

    D. 医疗及环境水体中病原微生物的抗药性演化

    E. 水产养殖病害纤毛虫的生物防治


    We are interested in the generation and change of biodversity, with a focus on mutation rate and life history evolution. The research models are quite broad, including cilaites, bacteria, yeast, etc. Our research strategy combines population genetics theory, experimental evolution, -omics sequencing, genetic techniques, and bioinformatic tools. The lab deems the training of indepedent researchers as our first task and research as the second. Graduate students would receive complete training of scientific research and multiple undergrad assistants are also provided for their research. We are now exploring the following topics:

    A. Phenotypic plasticity of ciliates, and its role in evolution

    B. Genome instability and evolution of marine microbial organisms

    C. Ecological dependence of mutation rate

    D. Antibiotic resistance evolution of pathogens in medical and natural environments

    E. Biocontrol of pathogenic ciliates in aquaculture

  • 招聘/招生


    招聘:协助拟加入人员申请中国海洋大学“青年英才工程”(http://rsc.ouc.edu.cn/04/50/c1485a66640/page.htm)等各层次人才计划;定期招收实验室管理、技术等科研助理岗位。

    招生:常年招收优秀本科生兼职助理、硕士生、博士生和博士后。

    具体信息请邮件咨询(longhongan@ouc.edu.cn)


  • 实验室负责人


    P.I.  

    龙红岸  授  博士生导师

    1982年8月出生 

    Hongan Long, Professor, Ph.D.

    E-mail: longhongan@ouc.edu.cn

    Tel: +86 532 8203 1723

    简历 Resume



  • 承担课题


    • 第15批国家“青千”(2019-2021)

    • 山东省“泰山学者”青年项目(2019.1-2024.1)

    • 国家自然科学基金国际(地区)合作项目(31961123002; 2019.10-2024.9)

    • 国家自然科学基金面上项目(31872228; 2019.1-2022.12)

    • 中央高校基本科研业务费(2018.1-2021.1)

    • 中国海洋大学“筑峰人才计划”启动经费(2018.9-2021.8)

    • Taishan Scholar' grant for young scientists, Shandong Province (2019.1-2024.1)

    • NSFC grants (No.31872228, 2019.1-2022.12, Phenotypic plasticity and its evolution in the ciliate Glauconema trihymene; No. 31961123002, 2019.10-2024.9, Global patterns of biodiversity in the ancient ciliate Paramecium)

    • Research grant from the Central Government of China (2018.1-2021.1)

    • Startup grant from Ocean University of China (2018.9-2021.8)


  • 讲授课程

    • 本科生课程:

    • 《微生物学》理论(40课时,2.5学分)与实验课(32课时,1学分,2-3个分班;春季学期);

    • 《模式生物发育与进化》(32课时,2学分,全校公共选修课,与其他5位老师合开;春季学期)

    • 研究生课程:

    • 《基于华为TaiShan服务器的微型生物大数据分析》(实践课,64课时,3学分;秋季学期)

  • 近期论文及成果


    *,corresponding author; #, co-first-author

    Recent publications

    Full texts of publications can be downloaded from researchgate

    1. Nguyen, D.; Wu, B.; Long*, H.; Zhang, N.; Patterson, C.; Simpson, S.; Morris, K.; Thomas, W.; Lynch, M.; Hao*, W. 2020. Variable spontaneous muation and loss of heterozygosity among heterozygous genomes in yeast. Molecular Biology and Evolution In Press.

    2. Pan, J.; Williams, E.; Sung, W.; Lynch, M.; Long*, H. 2020. The insect-killing bacterium Photorhabdus luminescens has the lowest mutation rate among bacteria. Marine Life Science and Technology In Press.

    3. Li, Y.; Chen, X.; Wu, K.; Pan, J.; Long*, H.; Yan*, Y. 2020. Characterization of simple sequence repeats (SSRs) in ciliated protists inferred by comparative genomics. Microorganisms 8(5): 662.

    4. Li, H.; Wu, K.; Ruan, C.; Pan, J.; Wang, Y.; Long*, H. 2019. Cost-reduction strategies in massive genomics experiments. Marine Life Science and Technology 1: 15-21. 

    5. Long*, H.; Miller, S.F.; Williams, E.; Lynch, M. 2018. Specificity of the DNA mismatch repair system (MMR) and mutagenesis bias in bacteria. Molecular Biology and Evolution 35(10):2414–2421.    

    6. Long, H.; Sung#, W.; Kucukyildirim#,S.; Williams,E.; Miller, S.;Guo, W.; Patterson, C.; Gregory, C.; Strauss, C.; Stone, C.; Berne, C.; Kysela, D.; Shoemaker, W.; Muscarella, M.; Luo, H.; Lennon, J.; Brun, Y.; Lynch*, M. 2018. Evolutionary determinants of genome-wide nucleotide composition. Nature Ecology and Evolution 2: 237-240.  

    7. Strauss, C.; Long*, H.; Patterson, C.; Te, R.; Lynch, M. 2017. Genome-wide mutation rate response to pH change in the coral reef pathogen Vibrio shilonii AK1. mBio 8 (4): e01021-17  

    8. Long, H.; Miller, S.F.; Strauss, C.; Zhao, C.; Cheng, L.; Ye, Z.; Griffin, K.; Te, R.; Lee, H.; Chen, C.; Lynch*, M. 2016. Antibiotic treatment enhances the genome-wide mutation rate of target cells. Proceedings of the National Academy of Sciences U.S.A. 113(18): E2498-E2505  

    9. Long*, H.; Kucukyildirim#, S.; Sung, W.; Williams, E.; Lee, H.; Ackerman, M.; Doak, T.; Tang, H.; Lynch, M. 2015. Background mutational features of the radiation-resistant bacterium Deinococcus radioduransMolecular Biology and Evolution 32(9): 2383-2392 

    10. Long*, H.; Sung, W.; Miller, S.F.; Ackerman, M.; Doak, T.; Lynch, M. 2015. Mutation rate, spectrum, topology, and context-dependency in the DNA mismatch repair-deficient Pseudomonas fluorescens ATCC948. Genome Biology and Evolution 7(1): 262-271 

    11. Farlow*, A.; Long#, H.; Arnoux, S.; Sung, W.; Doak, T.; Nordborg, M.; Lynch, M. 2015. The spontaneous mutation rate in the fission yeast Schizosaccharomyces pombeGenetics 201(2):737-744 

    12. Long*, H.; Paixão, T.; Azevedo, R.; Zufall, R. 2013. Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophilaGenetics 195(2): 527-540 

    13. Long*, H.; Zufall, R.A. 2010. Diverse modes of reproduction in the marine free-living ciliate Glauconema trihymeneBMC Microbiology 10(1): 108


  • 奖项

    2021 中国海洋大学优秀教师

    2019 中国海洋大学第21届天泰奖一等奖;中国海洋大学优秀班主任;中国海洋大学第20届五四青年奖

    2018 李氏基金会杰出创新奖

    2016 美国遗传学会DeLill Nasser遗传学职业发展奖

    2018 Li Foundation Heritage Prize-Excellence in Creativity

    2016 DeLill Nasser Award for Professional Development in Genetics, Genetics Society of America


  • 实验室人员


    People in the lab


    研究生:

    吴琨(2019级博士研究生),水生生物学,wukun@stu.ouc.edu.cn,细菌基因组的自发与诱导突变

    潘娇(2019级博士研究生),水生生物学,panjiao@stu.ouc.edu.cn,微生物的突变与表型可塑性

    蒋婉月(2020级博士研究生),水生生物学,jiangwanyue@stu.ouc.edu.cn,稀有突变的探测与原位突变率

    李海潮(2020级博士研究生),水生生物学,lihaichao@stu.ouc.edu.cn,纤毛虫原生动物的基因组演化

    林彤彤(2019级硕士研究生),生物学,lintongtong@stu.ouc.edu.cn,微生物基因组的极端演化

    倪家豪(2019级硕士研究生),生物工程,nijiahao@stu.ouc.edu.cn,纤毛虫多样性的产生与维持

    Pish Wattandilokchatkun (2019级硕士研究生,泰国留学生),水产养殖,pish.wtk@gmail.com,水产微生物基因组学

    周霞(2020级硕士研究生),水生生物学,zhouxia@stu.ouc.edu.cn,抗生素诱导突变

    郭慧琳(2020级硕士研究生),水生生物学,guohuilin@stu.ouc.edu.cn,种间作用影响下的基因组演化

    本科生:

    2017级:邓子光(生物科学)、兰烨琳(海洋渔业)、张渊渊(海洋渔业)

    2018级:韩玉敏(水产养殖)、冯若冰(生物技术)、姚栋基(生态)、程方(水产养殖)、李荟(生态)、石润芝(水产养殖)、包汉静(生态)、牛泽华(生态)、靳元江(水产养殖)、陈为哲(生态)、蔡雨君(生物技术)、高佳倩(水产养殖)

    2019级:高超(生物科学)、曹吉超(生物科学)、段云轩(生物科学)



  • 其他


    业余创作教育题材小说《转变 第一部》(ISBN号:978-7-5670-2188-4,出版中):

    链接:https://pan.baidu.com/s/1rnDdB3HSX_Q3Vw649Dw2Qw 

    提取码:2rge