• 研究方向


    微生物海洋学实验室目前有6名教师,全部具有博士学位,其中2名教授,4名副教授,另有2名博士后。实验室主要研究方向:1)海洋微生物的生物地球化学作用(包括微生物在海洋环境中的时空分布格局及环境响应,海洋微生物在碳循环、氮循环、硫循环中的作用等);2)海洋细菌的密度感应及密度感应淬灭(包括细菌密度感应对颗粒有机碳降解的调控作用、微生物耐药进化与逆转耐药进化等);3)海洋微生物的分离鉴定及资源开发(包括海洋微生物分离培养新技术的建立、新物种的分类鉴定、菌种库建设以及酶资源开发等)。

    近三年研究成果包括:1)首次发现海洋细菌能够合成冷室气体”DMS的前体物质DMSP,解析了细菌合成DMSP的通路,改变了DMSP主要由浮游植物合成的普遍认知,因此需要对DMSP的来源和气候效应进行重新评估;2)发现烃类降解菌在马里亚纳海沟底层水出现勃发,并在深渊底部沉积物中鉴定出了大量生物来源烷烃,指出烷烃可能是万米水体微生物的重要燃料3)揭示了近海底栖生境微生物的群落构建机制,提出了群落构建过程影响物种互作模式的新观点;4)首次报道了信号分子吲哚通过调控细菌内向转运泵来逆转细菌固有抗生素耐药性,深入揭示了信号分子对细菌抗生素耐药性的动态调控,为消除耐药细菌提供了新的思路。以上科学发现获得了领域内专家的一致认可,相关研究成果分别发表在顶级杂志Nature Microbiol, Nature Commun, ISME J, Microbiomembio上。

  • 承担课题

    国家自然科学基金重点项目1项

    国家自然科学基金委重大研究计划重点支持项目1项

    国家重点研发项目1项

    面上项目4项及青年项目1项


  • 近期论文及成果


    *通讯作者,#共同第一作者

    1.  Zheng Y, Wang J, Zhou S, Liu J, Xue C-X, Williams BT, Zhao X, Zhao L, Zhu X-Y, Sun C, Xiao T, Todd JD*, ZhangX-H*. 2020. Bacteria are important dimethylsulfoniopropionate producers in marine aphotic and high-pressure environments. Nature Communications, doi: 10.1038/s41467-020-18434-4

    2. Curson A, Liu J, Martinez AB, Green R, Chan Y, Carrion O, Williams BT, Zhang S-H, Yang G-P, Page PCB, Zhang X-H* & Todd JD*. 2017. Dimethylsulphoniopropionate biosynthesis in marine bacteria and identification of the key gene in this process. Nature Microbiolology, 2: e17009.

    3. Liu J, Zhu S, Liu X, Yao P, Ge T, Zhang X-H*. 2020. Spatiotemporal dynamics of the archaeal community in coastal sediments: assembly process and co-occurrence relationship. ISME J, 14:1463–1478..

    4. Zhong H, Lehtovirta-Morley L, Liu J, Zheng Y, Lin H, Song D, Todd JD, Tian J, Zhang X-H*. 2020. Novel insights into the Thaumarchaeota in the deepest oceans: their metabolism and potential adaptation mechanisms. Microbiome, 8:78.

    5.Wang X, Liu J, Liang J, Sun H, Zhang X-H*. 2020. Spatiotemporal dynamics of the total and active Vibrio spp. populations throughout the Changjiang estuary in China. Environ Microbiol, 2020, doi: 10.1111/1462-2920.15152

    6.Xue C-X, Zhang H, Lin H-Y, Sun Y, Luo D, Huang Y, Zhang X-H*, Luo H*. 2020. Ancestral niche separation and evolutionary rate differentiation between sister marine flavobacteria lineages. Environ Microbiol, 2020, 22: 3234–3247.

    7. Liu J, Zheng Y, Lin H, Wang X, Li M, Liu Y, Yu M, Zhao M, Pedentchouk N, Lea-Smith DJ, Todd JD, Magill CR, Zhang W-J, Zhou S, Song D, Zhong H, Xin Y, Yu M, Tian J*, Zhang X-H*. 2019. Proliferation of hydrocarbon degrading microbes at the bottom of the Mariana Trench. Microbiome, 7: 47.

    8. Liang J, Liu J, Wang X, Lin H, Liu J, Zhou S, Sun H, and Zhang X-H*. 2019. Spatiotemporal dynamics of free-living and particle-associated Vibrio communities in the northern Chinese marginal seas. Appl Environ Microbiol,  85:e00217-19.

    9. Wang Y*, Tian T, Zhang J-J, Jin X, Yue H, Zhang X-H, Du L-C, Bai F*, 2019, Indole reverses intrinsic antibiotic resistance by activating a novel dual-function importer. mBio, 10, e00676-19

    10. Yu R-L*, Wang J-Y, So LY, Harvey PJ, Shi J, Liang J-Z, Dou Q, Li X, Yan X-Y, Huang YH, Xu Q-L, Kaas Q, Chow HY, Wong KY, Craik DJ, Zhang X-H, Jiang T, and Wang Y*, 2020, Enhanced Activity against Multi-drug Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway. Journal of Medicinal Chemistry, DOI: 10.1021/acs.jmedchem.9b01563 (front cover paper)