研究团队
Research Groups

  • 研究方向

    围绕海洋环境污染引发的海洋生物安全等问题，利用多学科交叉的工具和方法，研究可持续生物材料的合成、性质及其在海洋生物中致病因子的检测与阻控中的应用。主要研究方向包括：

    （1）研究特定功能的可持续性纳米材料对海洋生物进行功能化修饰，开展人工进化研究； 

    （2）基于对纳米结构尺寸、形貌和表面性质的调控，研究纳米结构递送生物分子进入海洋生物细胞的过程、规律和机制，进行高效基因调控和编辑；

    （3）利用可持续特性生物纳米材料的识别功能，可视化检测和分离海洋生物中海洋弧菌、微塑料和重金属等致病因子。


  • 研究队伍

    王国庆    教授 博士生导师

    中国海洋大学“青年英才第一层次”教授

    Email: gqwang@ouc.edu.cn

    主页：https://www.x-mol.com/groups/gqwang


    主要研究方向及成果

    研究方向为水产生物与水产品安全，在基于可持续性材料的水产生物和水产品中危害物检测和防控方面取得了诸多创新成果。在Chem, Small, Nano Today, J. Hazard. Mater.和Chem. Eng. J.等国际主流刊物发表首作者及通讯作者论文50余篇，授权国家发明专利5项。主持国家自然科学基金面上、青年项目和省市项目多项。成果获日本“Joint Research Center for Materials and Devices”共同研究奖（2022）、省高校青年创新团队支持计划人选（2021）、省青年科技人才托举工程人选（2018）。受邀在韩国毒理-环境学会KSOT International Symposium、环太平洋化学大会（Pacifichem2021）和日本生体高分子研究会等国际会议和高校学术报告近10次。兼任中国海洋湖沼协会海岸带可持续发展分会理事（2021‒），曾任日本理化学研究所客座研究员（2018‒2021）、日本学术振兴会特别研究员（2012‒2014）。在教育类顶尖期刊J. Chem. Edu.发表封面论文2篇；共事的学生多人获国家奖学金、学术(实践)创新奖学金和研究生优秀成果奖等奖励，多人获推荐赴美国西北大学、日本北海道大学等海外著名高校留学。


    Prof. Dr. Guoqing Wang

    Website: https://www.x-mol.com/groups/gqwang


    Education and Research Experience

    Professor, Ocean University of China (2018-present)

    Contract Researcher, RIKEN (Japan) (2014‒2018)

    Postdoc., University of California, Riverside (USA) (2013‒2014)

    Ph.D., Chemical Science and Engineering, Hokkaido University (Japan) (2010‒2013)

    Research Assistant, Yantai Institute for Coastal Zone Research, CAS (2009-2010)

    M. Sc., Bionano Science, Hanyang University (South Korea) (2007‒2009)

    B. E., Chemical Engineering, Qufu Normal University (2003‒2007)


    Research Interests

    We are an interdisciplinary research team with programs centered on materials-engineered biointerfaces and organisms that allows hazardous species and molecules of interest to be traced, assessed, and manipulated. Aiming at safeguarding marine lives, the marine environment, and aquatic products, the current research direction includes (1) development of biomolecules-inspired nanoprobes and materials, and (2) materials-driven gene regulation and functional evolution of marine organisms.


  • 承担课题

    国家自然科学基金面上项目：金纳米簇介导的鳗弧菌基因调控及其在大菱鲆仔鱼白鳍病防治中的应用（2024-2028）

    国家自然科学基金青年项目：三维多级金纳米结构的化学合成及其光学性质解析（21805263）（2019-2022）

    山东省自然科学基金青年项目：基于金纳米结构表面 DNA walker 的赭曲霉素 A 痕量检测（2019-2022）

    山东省重点研发计划软科学项目：光刺激响应的DNA单碱基配对调控纳米颗粒自组装（2025-2027）

    山东省高校青年创新团队支持计划：食源致病微生物智能核酸分析仪的研发（2022-2025）

    青岛市科技惠民示范专项：核酸适配体介导新型金纳米探针响应机制及水产品中重金属手机智能检测方法的建立（2022-2024）


  • 近期论文及成果

    2024

    1. H. Yin, Q. Zhang, S. Hu, X. Sun, L. Peng, H. Zhao, Q. Kong, H. Mitomo, Y. Matsuo, K. Ijiro, G. Wang*, Hierarchical Au Nanoflowers Formed in an Ionic Liquid/Water System for Bacterial Inhibition. ACS Applied Nano Materials 2024, 7, 16998-17008.

    2. L. Wang, Z. Wang, F. Liu, X. Zhang, J. Huang, G. Wang*, Programmable Plasmonic Hydrogel Thermometers Actuated by DNA Breathing. Advanced Materials Technologies 2024, 2400243.

    3. X. Zhang, Y. Tian, Y. Shi, J. Liu, C. Zhao, C.-C. Chang, T. Takarada, M. Maeda, G. Wang*, Naked-Eye LAMP Assay of M. Tuberculosis in Sputum by In Situ Au Nanoprobe Identification: For Invitro Diagnostics of Tuberculosis. ACS Infectious Diseases 2024, 10, 2668-2678.

    4. F. Zhao, F. Liu, C. Gao, G. Wang*, Y. Zhang, F. Yu, J. Tian, K. Tan, R. Zhang, K. Liang, Z. Lian, J. Guo, B. Kong*, J. Ge, H. Xin*, Interfacing Exogenous Stents with Human Coronary Artery by Self-Assembled Coating: Designs, Functionalities and Applications. NPG Asia Materials 2024, 16: 28.

    5. Q. Zhang, J. Fu, H. Lin, G. Xuan, W. Zhang, L. Chen, G. Wang*. Shining Light on Carbon Dots: Toward Enhanced Antibacterial Activity for Biofilm Disruption. Biotechnology Journal 2024, 19: 2400156. 

    6. Y. Shi, S. Nakamura, H. Mitomo, Y. Yonamine, G. Wang, K. Ijiro. Plasmonic Circular Dichroism-Based Metal Ion Detection Using Gold-Nanorod-DNA complexes. Chemical Communications 2024, in press

    7. M. Huang, C. Si, C. Qiu, G. Wang*. Microplastics Analysis: From Qualitative to Quantitative. Environmental Science: Advances 2024, in press

    2023

    8. Y. Li, J. Fu, L. Peng, X. Sun, G. Wang*, Y. Wang, L. Chen*. A Sustainable Emulsion for Separation and Raman Identification of Microplastics and Nanoplastics. Chemical Engineering Journal 2023, 469, 143992 (DOI: 10.1016/j.cej.2023.143992)

    9. L. Wang, Z. He, Q. Chen, G. Wang*, X. Liang, T. Takarada, M. Maeda. Refreshing DNA-Based Nanoprobes by Alcohol for Heavy Metal Detection: Towards Sustainable Sensing Nanomaterials. ACS Sustainable Chemistry and Engineering 2023, 11, 3611-3620 (Front Cover)

    10. J. Fu, N. Liu, Y. Peng, G. Wang*, X. Wang, Q. Wang, M. Lv, L. Chen*. An Ultra-Light Sustainable Sponge for Elimination of Microplastics and Nanoplastics. Journal of Hazardous Materials 2023, 456, 131685

    11. S. Cheng, Z. Lou, L. Zhang, H. Guo, Z. Wang, C. Guo, K. Fukuda, S. Ma, G. Wang, T. Someya, H.-M. Cheng, X. Xu* Ultrathin Hydrogel Films Toward Breathable Skin-Integrated Electronics. Advanced Materials 2023, 2206793

    12. J. Fu, L. Zhang, K. Xiang, Y. Zhang, G. Wang*, L. Chen*. Microplastics-Contaminated Antibiotics as an Emerging Threat to Mammalian Liver: Enhanced Oxidative and Inflammatory Damages. Biomaterials Science 2023, 11, 4298-4307

    13. F. Liu, H. Wu, Q. Chen, J. Gao, G. Wang*. Demonstration of a Magic Reaction: Accelerating DNA Functionalization of Gold Nanoparticles by Freezing. Journal of Chemical Education 2023, 100, 2009–2014 (Front Cover)

    14. Z. He, Q. Chen, S. Ding, G. Wang*, T. Takarada, M. Maeda. Suppressed DNA Base Pair Stacking of Gold Nanoparticles in an Alcoholic solvent for Enhanced Ochratoxin A Detection in Baijiu. Analyst 2023, 148, 1291-1299

     

    15. H. Cong, H. Ding, G. Wang, X. Wang*, L. Chen. Smartphone-Assisted Multicolor Hypoxanthine Sensing for On-Site Freshness Assessment of Aquatic Products. Sensors and Actuators B: Chemical 2023, 379, 133246

    2022

    16. K. Xiang, Z. He, J. Fu, G. Wang*, H. Li, Y. Zhang*, S. Zhang, L. Chen. Microplastics Exposure as an Emerging Threat to Ancient Lineage: A Contaminant of Concern for Abnormal Bending of Amphioxus via Neurotoxicity. Journal of Hazardous Materials 2022, 438, 129454

    17. L. Kong, L. Wang, Y. Shi, L. Peng, X. Liang, G. Wang*, H. Mitomo, T. Takarada, K. Ijiro, M. Maeda. DNA-Functionalized Silver Nanoparticles in an Alcoholic Solvent for Environment-Dictated Multimodal Actuation. ACS Applied Nano Materials 2022, 5, 10321-10330

    18. Y. Shi, Q. Chen, Y. Liu, G. Wang*. Capability of Au Nano-Rhombic Dodecahedrons in Label-Free Colorimetric Assay: Application to the Determination of Sulphion and Mercury(II) Ion. Analyst 2022, 147, 3578-3584

    19. Q. Li, F. Liu, Y. Shi, X. Sun, B. Li, X. Liang, G. Wang*. Hierarchical Au Nanoisland Arrays for Anticounterfeiting Surface-Enhanced Raman Scattering Stamps. ACS Applied Nano Materials 2022, 5, 965-971.

    20. Y. Li, L. Peng, J. Fu, X. Dai, G. Wang*. A Microscopic Survey on Microplastics in Beverages: The Case of Beer, Mineral Water and Tea. Analyst 2022, 147, 1099-105

    21. J. Fu, Y. Li, L. Peng, W. Gao, G. Wang*. Distinct Chemical Adsorption Behaviors of Sulfanilamide as a Model Antibiotic onto Weathered Microplastics in Complex Systems. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2022, 648, 129337

    22. J. Han, F. Liu, J. Qi, M. Arabi, W. Li, G. Wang, L. Chen*, B. Li*. A ZnFe2O4-Catalyzed Segment Imprinted Polymer on a Three-Dimensional Origami Paper-Based Microfluidic Chip for the Detection of Microcystin. Analyst 2022, 147, 1060-1065.

    23. J. C. Mba, H. Mitomo,* Y. Yonamine, G. Wang, Y. Mastuo, K. Ijiro*. Hysteresis in the Thermo-Responsive Assembly of Hexa(ethylene glycol) Derivative-Modified Gold Nanodiscs as an Effect of Shape. Nanomaterials 2022, 12, 1421 (, Open-Access, Editor's Choice; Invited paper from the Special Issue of  Self-Assembly of Nanoparticles: Strategy, Properties, and Applications)

    24. L. Zhang, D. J. McClements, Z. Wei, G. Wang, X. Liu, F. Liu*. Delivery of Synergistic Polyphenol Combinations using Biopolymer-Based Systems: Advances in Physicochemical Properties, Stability and Bioavailability. Critical Reviews in Food Science and Nutrition 2020, 60, 2083-2097.

    25. L. Li, R. An, J. Tang, Z. Sui, G. Wang, M. Komiyama,* X. Liang*. Facile Characterization of Topology of DNA Catenanes. Biophysical Journal 2020, 118:1702-1708.

    2021

    26. L. Zhang, X. Ma, G. Wang*, X. Liang, H. Mitomo, A. Pike, A. Houlton, K. Ijiro*. Non-Origami DNA for Functional Nanostructures: from Structural Control to Advanced Applications. Nano Today 2021, 39, 101154.

    27. L. Wang, X. Wang, L. Cheng, S. Ding, G. Wang*, J. Choo,* L. Chen*. SERS-Based Test Strips: Principles, Designs and Applications. Biosensors and Bioelectronics 2021, 189, 113360.

    28. L. Wang, Y. Shi, G. Wang*, X. Liang, T. Takarada, M. Maeda. Range-Tunable Plasmon Switching of Gold Nanorods by Terminal Breathing of Surface-Grafted DNA in Alcoholic Solvents. Journal of Materials Chemistry C 2021, 9, 5105-5112. (Back Cover)

    29. L. Cheng, L. Wang, Z. He, X. Sun,* Y. Li, G. Wang*, Y. Tian, T. Takarada, M. Maeda, X. Liang. Plasmon Switching of Gold Nanoparticles through Thermo-Responsive Terminal Breathing of Surface-Grafted DNA in Hydrated Ionic Liquid. Analyst 2021, 146, 4154-4160.

    30. Z. He, S. Ding, L. Wang, G. Wang*, X. Liang, T. Takarada, M. Maeda. Introducing DNA Nanosensor to Undergraduate Students: Rapid Non-Cross-Linking Aggregation of DNA-Functionalized Gold Nanoparticles for Colorimetric DNA Assay. Journal of Chemical Education 2021, 98, 3553-3559. (Front Cover)

    31. S. Ding, L. Wang, Z. He, Z Sui, G. Wang*, T. Takarada, M. Maeda, X. Liang. Identifying Exogenous DNA in Liquid Foods by Gold Nanoparticles: Potential Applications in Traceability. ACS Food Science and Technology 2021, 1, 605-613.

    32. Z. He, L. Zhang, G. Peng, G. Wang*, X. Liang. Chemical Redox-Modulated Etching of Plasmonic Nanoparticles for Nitrite Detection: Comparison among Gold Nanosphere, Nanorod, and Nanotriangle. Journal of Analysis and Testing 2021, 5, 350-359

    33. Z. He, G. Wang*, X. Liang, T. Takarada,* M. Maeda. DNA Base Pair Stacking Assembly of Anisotropic Nanoparticles for Biosensing and Ordered Assembly. Analytical Sciences 2021, 37, 415-423. (Invited paper from the Special Issue of Analytical Biomaterials)

    34. L. Yan, J. Mu, P. Ma, Q. Li, P. Yin, X. Liu, Y. Cai, H. Yu, J. Liu, G. Wang, A. Liu*. Gold Nanoplates with Superb Photothermal Efficiency and Peroxidase-like Activity for Rapid and Synergistic Antibacterial Therapy. Chemical Communications 2021, 57, 1133-1136.

     

    2020

    35. Y. Shi, Q. Li, Y. Zhang, G. Wang*, Y. Matsuo, X. Liang, T. Takarada, K. Ijiro, M. Maeda. Hierarchical Growth of Au Nanograss with Intense Built-In Hotspots for Plasmonic Applications. Journal of Materials Chemistry C 2020, 8, 16073-16082

    36. W. Diao, G. Wang*, L. Wang, L. Zhang, S. Ding, T. Takarada, M. Maeda, X. Liang. Opposite Effects of Flexible Single-Stranded DNA Regions and Rigid Loops in DNAzyme on Colloidal Nanoparticle Stability for Turn-On Plasmonic Detection of Lead Ions. ACS Applied Bio Materials 2020, 3, 7003-7010.

    37. L. Wang, G. Wang*, Y. Shi, L. Zhang, R. An, T. Takarada, M. Maeda, X. Liang. Accelerated Non-Crosslinking Assembly of DNA-Functionalized Nanoparticles in Alcoholic Solvents: Towards Application in Identification of Clear Liquors. Analyst 2020, 145, 3229-3235. (Inside Front Cover)

    38. Z. He, H. Yin, C.-C. Chang, G. Wang, X. Liang. Interfacing DNA with Gold Nanoparticles for Heavy Metal Detection. Biosensors 2020, 10, 167.