吕志一 副教授 博士生导师
山东省泰山学者青年专家（2020-2024）
中国海洋大学“青年英才工程”第三层次特聘教授
E-mail: lvzhiyi@ouc.edu.cn
Tel：0532-82032732
教育背景：
2002年9月-2006年6月，西北农林科技大学，生物科学。本科；
2007年9月-2010年6月，西北农林科技大学，发育生物学，硕士；
2010年11月-2014年12月，德国哥廷根大学，发育生物学，博士；
科研工作经历：
2014年12月-2019年9月，德国哥廷根大学医学中心从事博士后研究。
2019年10月-，中国海洋大学海洋生命学院，进化所形态发生与进化实验室，副教授。
2020年2月-2020年4月，德国马尔堡大学客座研究员。
研究方向和研究成果：
胚胎发育过程中细胞间相互协调的分子生物学与生物物理学机制。利用果蝇囊胚、果蝇羊浆膜细胞、海鞘脊索、水螅等为实验模型，通过分子遗传学、生物化学、显微成像和定量分析等手段，研究细胞周期、细胞骨架、细胞连接在胚胎发育过程中的动态变化及其调控过程。研究结果相继发表在Current Biology、Journal of cell science、Development、Biophysical Journal、Angewandte Chemie、EMBO Rep等国际主流期刊。
Asso. Prof. Zhiyi LV:
Education:
2002.09 - 2006.07 Bachelor in Biology, Northwest A&F University, China.
2007.09 - 2010.07 Master in Developmental biology, Northwest A&F University, China.
2010.10 – 2014.10 Doctoral study in Gene and Development project. Göttingen University, Germany.
Academic appointments：
2014.11 – 2019.10 Post-doc researcher with Jörg Großhans in Göttingen medical school. Germany.
2019.10-now Associate Professor in Ocean University of China, IEMB and College of Marine Life Science.
2020.02-2020.04 Guest Scientist in Marburg University, Department of Developmental genetics.
Research focus:
In order to form complex tissue architecture, the participating cells need to coordinate with each other. How it is achieved is a fundamental question in developmental biology. Using Drosophila, Ciona and hydra embryo as model systems, we are applying biochemical and molecular genetic approaches in combination with quantitative analysis and biophysical modeling to dissect the molecular mechanism of cell-cell communication during morphogenesis. Specifically, we are interested in the following questions: How is cell cycle regulation embedded in developmental program? How do cells communicate with each other via mechano-chemical signal transduction? How are the material properties of living cells regulated and how do they contribute to embryogenesis?
Publications:
1. Zhiyi Lv*, Jan Rosenbaum, Stephan Mohr, Xiaozhu Zhang, Deqing Kong, Helen Preiß;, Sebastian Kruss, Karen Alim; Timo Aspelmeier, Jörg Großhans*. The emergent Yo-yo movement of nuclei driven by cytoskeletal remodeling in pseudo-synchronous mitotic cycles, Current Biology (in press).
2. Zhiyi Lv, Jorge de-Carvalho, Ivo A. Telley, Jörg Großhans* Drosophila syncytial embryo: a simple tissue model for studying cytoskeletal mechanics and dynamics. Journal of Cell Science (in press)
3. Gabriele Selvaggio, Alexey Chizhik, Robert Nißler, llyas Kuhlemann, Daniel Meyer, Loan Vuong,Helen Preiß, Niklas Herrmann, Florian A. Mann, Zhiyi Lv, Tabea A. Oswald, Alexander Spreinat, Luise Erpenbeck, Jörg Großhans, Volker Karius, Andreas Janshoff, Juan Pablo Giraldo, Sebastian Kruss*. Exfoliated near infrared fluorescent silicate nanosheets for (bio)photonics. Nature communications. (2020) 11:1495.
4. Zhiyi Lv, Qiongxuan Lu, Bo Dong*. Morphogenesis: a focus on marine invertebrates. Marine Life Science and Technolgy. (2019) 1:28-40.
5. Deqing Kong*, Zhiyi Lv, Mattias Haering, Benjamin Lin, Fred Wolf, Jörg Großhans: In vivo optochemical control of cell contractility at signle cell resolution. EMBO Reports.2019, 20:e47755.
6. Florian Mann, Zhiyi Lv, Jörg Grosshans, Felipe Opazo, Sebastian Kruss*: Nanobody Conjugated Nanotubes for Targeted Near‐Infrared in vivo Imaging and Sensing. Angewandte Chemie 05/2019; 131(33)., DOI:10.1002/ange.201904167
7. Franz Kaiser, Zhiyi Lv, Daniel Marques Rodrigues, Jan Rosenbaum, Timo Aspelmeier, Jörg Großhans, Karen Alim*: Mechanical Model of Nuclei Ordering in Drosophila Embryos Reveals Dilution of Stochastic Forces. Biophysical Journal 04/2018; 114(7):1730-1740., DOI:10.1016/j.bpj.2018.02.018
8. Zhiyi Lv, Jan Rosenbaum, Timo Aspelmeier, Jörg Großhans*: A molecular guillotine reveals an interphase function of Kinesin-5. Journal of Cell Science 01/2018; 131(3)., DOI:10.1242/jcs.210583
9. Anja Schmidt#, Zhiyi Lv#, Jörg Großhans: ELMO and Sponge specify subapical restriction of Canoe and formation of the subapical domain in early Drosophila embryos. Development 12/2017; 145(2):dev.157909., DOI:10.1242/dev.157909
10. Zhiyi Lv, Jörg Großhans*: A Radial Actin Network in Apical Constriction. Developmental Cell 11/2016; 39(3):280-282., DOI:10.1016/j.devcel.2016.10.017
11. Franziska Winkler#, Maheshwar Gummalla#, Lutz Künneke#, Zhiyi Lv, Annette Zippelius, Timo Aspelmeier, Jörg Grosshans: Fluctuation Analysis of Centrosomes Reveals a Cortical Function of Kinesin-1. Biophysical Journal 09/2015; 109(5):856-68., DOI:10.1016/j.bpj.2015.07.044
12. Shuling Yan#, Zhiyi Lv#, Moritz Winterhoff#, Christian Wenzl, Thomas Zobel, Jan Faix, Sven Bogdan*, Jörg Großhans*: The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization. Journal of Cell Science 02/2013; 126(8)., DOI:10.1242/jcs.118422
*通讯作者
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