高瞻 副教授 硕士生导师
E-mail: gaozhan@ouc.edu.cn
Tel: 0532-82032439
一、学习工作简历
2006.9-2010.6，中国海洋大学，生物科学专业，学士；
2010.9-2015.6，中国海洋大学，海洋生物学专业，博士；
2015.9-2018.12，中国海洋大学，海洋生命学院，讲师；
2019.1-至今，中国海洋大学，海洋生命学院，副教授。
二、研究方向
比较免疫学，聚焦于文昌鱼免疫与进化。
三、科研项目
1、国家自然科学基金青年项目“文昌鱼VCBP免疫识别和效应功能研究：VCBP类抗体功能探索”，2017-2019，已结题。
2、国家自然科学基金面上项目“垂体-甲状腺轴起源探索：文昌鱼促甲状腺素β亚基及其受体的相互作用和功能鉴 定”，2018-2021，参加。
3、国家自然科学基金面上项目“CRIP1在胚胎血管发育中的功能和作用机制研究”，2019-2022，参加。
四、代表性论著目录
（一）发表文章（*示通讯作者）：
1. Gao Zhan, Qu Baozhen, Yao lan, Ma Zengyu, Zhang Shicui*. Identification and functional characterization of amphioxus Miple, ancestral type of vertebrate midkine/pleiotrophin homologues. Developmental & Comparative Immunology, 2018, 89:31-43.
2. Gao Zhan, Ma Zengyu, Qu Baozhen, Jiao Deyan, Zhang Shicui*. Identification and characterization of properdin in amphioxus: Implications for a functional alternative complement pathway in the basal chordate. Fish & Shellfish Immunology, 2017, 65:1-8.
3. Gao Zhan,Qu Baozhen, Ma Zengyu, Jiao Deyan, Ji Guangdong*, Zhang Shicui*. Identification and functional characterization of a novel member of low density lipoprotein receptor-related protein (LRP)-like family in amphioxus. Gene, 2017, 618:42-48.
4. Gao Zhan, Li Mengyang, Ma Jie, Zhang Shicui*. An amphioxus gC1q protein binds human IgG and initiates the classical pathway: Implications for a C1q-mediated complement system in the basal chordate. European Journal of Immunology, 2014, 44(12): 3680-3695.
5. Gao Zhan, Li Mengyang, Wu Jie, Zhang Shicui*. Interplay between invertebrate C3a with vertebrate macrophages: Functional characterization of immune activities of amphioxus C3a. Fish & Shellfish Immunology, 2013, 35(4): 1249-1259.
6. Qu Baozhen, Ma Zengyu, Zhang Yu, Gao Zhan*, Zhang Shicui*. Characterization of a novel protein identified by proteomics analysis as a modulator of inflammatory networks in amphioxus. Fish & Shellfish Immunology, 2020, 96:97-106.
7. Yao Lan, Qu Baozhen, Ma Zengyu, Chen Ying, Tan Yunxia, Gao Zhan*, Zhang Shicui*. Lectin-like and bacterial-agglutinating activities of heat shock proteins Hsp5 and Hsp90α from amphioxus Branchiostoma japonicum. Fish & Shellfish Immunology, 2019, 95:688-696.
8. Ma Zengyu, Qu Baozhen, Zhong Shenjie, Yao Lan, Gao Zhan*, Zhang Shicui*. Subtle Difference Generates Big Dissimilarity: Comparison of Enzymatic Activity in KL1 and KL2 Domains of Lancelet Klotho. Marine Biotechnology (NY), 2019, 21(4):448-462.
9. Guo Xiaomin, Xin Jiajing, Wang Peng, Du Xiaoyuan, Ji Guangdong, Gao Zhan*, Zhang Shicui*. Functional characterization of avidins in amphioxus Branchiostoma japonicum: Evidence for a dual role in biotin-binding and immune response. Developmental & Comparative Immunology, 2017, 70: 106-118.
10. Qu Baozhen, Yang Shuangshuang, Ma Zengyu, Gao Zhan*, Zhang Shicui*. A new LDLa domain-containing C-type lectin with bacterial agglutinating and binding activity in amphioxus. Gene, 2016, 594(2): 220-228.
11. Li Mengyang, Gao Zhan, Ji Dongrui, Zhang Shicui*. Functional characterization of growth hormone (GH)-like homolog in amphioxus reveals an ancient origin of GH/GH receptor system. Endocrinology, 2014, 155(12): 4818-4830.
12. Li Mengyang, Gao Zhan, Wang Yu, Wang Hui, Zhang Shicui*. Identification, expression and bioactivity of hexokinase in amphioxus: Insights into evolution of vertebrate hexokinase genes. Gene, 2014, 535(2): 318-326.
13. Wang Yu, Wang Hui, Li Mengyang, Gao Zhan, Zhang Shicui*. Identification, expression and regulation of amphioxus G6Pase gene with an emphasis on origin of liver. General and Comparative Endocrinology, 2015. 214:9-16.
14. Wang Lixia, Wang Yuan, Li Zhaohe, Gao Zhan, Zhang Shicui*. Functional characterization of protein 4.1 homolog in amphioxus: Defining a cryptic spectrin-actin-binding site. Scientific Reports, 2013.3: 2873.
15. Sun Chen, Hu Lili, Liu Shousheng, Gao Zhan, Zhang Shicui*. Functional analysis of domain of unknown function (DUF) 1943, DUF1944 and von Willebrand factor type D domain (VWD) in vitellogenin2 in zebrafish. Developmental and Comparative Immunology, 2013. 41: 469-476.
（二）英文专著：
1. Gao Zhan, Zhang Shicui*. Cephalochordata: Branchiostoma. In “Advances in Comparative Immunology” (Ed. by Edwin L. Cooper), 2018. Springer. Pages 593-636.
Dr. Zhan GAO:
Ph.D., Marine Biology, Ocean University of China (2015)
Research Interests:
Functions of immune-relevant genes of amphioxus
