海洋生物多样性与进化研究所于2010年成立，经机构改革，2020年起成为校内独立二级单位。作为我校海洋生物学国家重点学科、海洋生物多样性与进化教育部重点实验室、生物学一级学科博士点的构成之一，所内各团队主要聚焦于海洋重要模式生物、重要功能类群的多样性、发育与进化等基础生物学领域，并在纤毛虫生物学、模式动物发育、再生与进化、表观遗传学、海洋微型生物的环境生物学等领域取得了国内外公认的成就。

研究所成员目前共计58人，包括专职成员29人、跨院组合兼职成员29人。成员中包括教授37人、副教授16人、中级职称1人、行政管理人员4人。

专职成员中包括中科院院士1人、“国家杰青”与“长江特聘教授”3人、国家“四青”级人才8人；此外，山东省“泰山学者”特聘教授、山东省“杰青”、山东省“青年泰山学者”、教育部引才专项、教育部“新世纪人才计划”等荣誉称号入选者14人。

进化所目前专职成员共29人(点击以下专任教师姓名可链接查看简历)：

教授： 包立随、高  凤、高  珊、李红岩、刘志清、龙红岸、宋微波、苏  颖、孙  进、田  苗、王国庆、王平原、阎  莹、张士璀、张伟鹏、赵呈天、赵  龙、孔德清、姜  勇、隗健凯

副教授： 高  瞻、吕志一、王  哲、张蕴慧、谢海波

行政及管理人员： 张  川、马洪钢、刘宇杰、杨  伟

主要研究方向与领域：

● 原核及真核微生物多样性、进化、表观遗传调控与演化机制

主要探讨原核、真核、病毒等微型生物的多样性、生物地理学、细胞学、系统发育、表观遗传学、群体遗传学、基因组进化、大数据库构建等基础生物学问题。相关研究包括：（1）未明生境中纤毛虫原生动物的多样性、区系与地理分布格局；纤毛门内纲-目-科等高阶阶元间的亲缘关系及系统发育；进化节点类群生殖期间细胞器结构分化及模式形成与命运；（2）以四膜虫、草履虫等为材料，以DNA甲基化、小RNA为主的表观遗传学及染色质生物学；模式类群有性生殖、细胞分裂等生理过程中的重要事件与调控机制；（3）中国边缘海、极地、深渊等生境内病毒、细菌-古菌等微生物、微型-微微型浮游生物多样性、群落结构、功能及其与宿主、生物地理学、环境适应机理和生物地球化学作用研究；（4）微生物在环境胁迫下的遗传变异产生与适应性演化机制，以及功能性状形成与生态适应的遗传基础。

● 模式动物的发育、再生、重要器官的功能进化与调控

以多种模式动物为材料，研究其发育、再生过程中的基因表达、功能、调控网络和信号通路以及重要组织-器官的功能和演化等。主要方向包括：（1）以斑马鱼、文昌鱼等为模式动物，从组织、细胞、分子等层次研究神经内分泌、免疫和感觉系统的起源与演化，勾画脊椎动物起源与演变图景，探讨机体与器官发育及衰老的分子机理，解析关键免疫分子结构和功能多样性的发生与进化机制；（2）以斑马鱼、果蝇为模式生物，围绕重要器官，解析纤毛的作用机理及其调控器官发育的分子机制；解构心脏等成体重要组织器官再生的生物学过程及调控机制；以造血系统等为核心，阐释细胞命运决定及分化的分子调控机理；（3）以海鞘形态发生、早期胚胎发育与基因表达变化、环境适应等为关注点，阐明形态建成与适应性演化的细胞学过程、遗传基础及分子调控机制，揭示重要发育信号通路的转导机制；（4）以果蝇等为材料，探讨多细胞动物发育过程中的细胞间动态互作调控机制。

● 进化节点生物类群的多样性与系统演化

围绕海洋中各类典型生境中重要生物类群的生物地理学、多样性与演化，主要方向包括：（1）聚焦海洋化能合成生态系统（热液、冷泉、浅海沉积环境）中贝类等无脊椎类群，解析其演化及谱系间的系统发育关系，探讨物种形成、适应性演化、动物与微生物的共生关系；（2）以珊瑚、海绵等无脊椎动物、共生微生物以及细菌生物被膜为核心，探讨次级代谢产物的化学结构、合成途径及生物活性，解析代谢产物干预人类疾病的分子机制；（3）开发与构建虾蟹等海洋动物细胞的体外培养体系及其基因转移技术；探讨文昌鱼和蝾螈组织器官的再生机制及演化；（4）聚焦海洋藻类基因突变种库构建、重要经济藻类环境适应的生理机制和遗传基础以及藻菌互作的分子机制; 以经济鱼类为研究对象，构建纳米技术改造的分子工具，实现针对免疫与抗逆等相关关键基因的精准递送与靶向调控。

Institute of Evolution & Marine Biodiversity, OUC

The Institute of Evolution and Marine Biodiversity was established in 2010.

As an integral component of the National Key Discipline of Marine Biology, Key Laboratory of Evolution and Marine Biodiversity (Ministry of Education), and the doctoral program in Biology at Ocean University of China, the Institute is dedicated to fundamental biological research on the diversity, evolution, development, and regulatory mechanisms of marine model organisms and ecologically important taxa. Its research teams have achieved internationally recognized accomplishments in ciliate biology, developmental biology of model organisms, regeneration, epigenetics, and environmental microbiology.

Main research fields:

● Diversity, Evolution, Epigenetic Regulation, and Evolutionary Mechanisms in Microbes

Research in this area focuses on fundamental biological questions concerning the diversity, biogeography, cell biology, phylogeny, epigenetics, population genetics, genome evolution, and large-scale database construction of microorganisms, including prokaryotes, eukaryotes, and viruses. Major research topics include: 1) Diversity, biogeography, and distribution patterns of ciliates in poorly explored habitats; phylogenetic relationships among major taxonomic groups within the phylum Ciliophora; and organelle differentiation, pattern formation, and developmental fate during reproduction in evolutionarily significant ciliate lineages. 2) Epigenetic and chromatin biology studies in model ciliates such as Tetrahymena and Paramecium, with particular emphasis on DNA methylation and small RNA-mediated regulation; investigation of key events and regulatory mechanisms governing sexual reproduction and cell division. 3) Diversity, community structure, ecological functions, and environmental adaptations of viruses, bacteria, archaea, pico- and nanoplankton inhabiting China's marginal seas, polar regions, and deep-sea ecosystems, as well as their interactions with hosts, biogeographic distributions, and roles in biogeochemical cycles. 4) Genetic variation and adaptive evolutionary mechanisms of microorganisms under environmental stress, together with the genetic basis underlying functional trait evolution and ecological adaptation.

● Development, Regeneration, Functional Evolution, and Regulation of Major Organs in Model Animals

Using a variety of model organisms, research in this area investigates gene expression, gene function, regulatory networks, signaling pathways, developmental processes, regenerative mechanisms, and the functional evolution of important tissues and organs. Major research directions include: 1) Using zebrafish, amphioxus, and other model organisms to explore the origins and evolution of neuroendocrine, immune, and gustatory systems at tissue, cellular, and molecular levels; reconstructing the evolutionary history of vertebrates; elucidating molecular mechanisms underlying organismal development and aging; and investigating the origins and evolution of structural and functional diversity in key immune molecules. 2) Using zebrafish and Drosophila as model systems to uncover the biological functions of cilia and the molecular mechanisms by which cilia regulate organ development; dissecting the biological processes and regulatory mechanisms of regeneration in major adult organs such as the heart; and elucidating molecular mechanisms governing cell fate determination and differentiation, particularly within the hematopoietic system. 3) Focusing on morphogenesis, early embryonic development, gene expression dynamics, and environmental adaptation in ascidians to reveal the cellular processes, genetic foundations, and molecular regulatory mechanisms underlying body-plan formation and adaptive evolution, as well as the signaling mechanisms of key developmental pathways. 4) Using Drosophila and other model organisms to investigate the regulatory mechanisms governing dynamic intercellular interactions during multicellular development.

● Diversity and Evolutionary Relationships of Key Evolutionary Lineages

Research in this area focuses on the biogeography, diversity, and evolutionary history of important biological groups inhabiting representative marine ecosystems. Major research directions include: 1) Investigating mollusks and other invertebrates inhabiting marine chemosynthetic ecosystems, including hydrothermal vents, cold seeps, and shallow-water sedimentary environments, to elucidate their evolutionary history, phylogenetic relationships, speciation processes, adaptive evolution, and symbiotic associations with microorganisms. 2) Using corals, sponges, their associated microorganisms, and bacterial biofilms as model systems to characterize the chemical structures, biosynthetic pathways, and biological activities of secondary metabolites, and to elucidate the molecular mechanisms through which these compounds influence human diseases. 3) Developing in vitro cell culture systems and gene transfer technologies for marine animals such as shrimp and crabs; investigating the mechanisms and evolutionary origins of tissue and organ regeneration in amphioxus and salamanders. 4) Establishing mutant libraries in marine algae; elucidating the physiological mechanisms and genetic basis of environmental adaptation in economically important algal species; investigating molecular mechanisms of algae–microbe interactions; developing nanotechnology-enhanced molecular tools for the precise delivery and targeted regulation immunity and stress resilience genes in economically important fish species.