动物发育在细胞学上依赖于各种细胞行为，包括细胞形变、增值、黏附、迁移和分化等。在多层调控机制的确保下，多种细胞行为协同进行，驱动组织形态变化，进而保证胚胎发育的顺利进行。本实验室以果蝇为主要模型，同时开发新型模式系统，通过遗传学、生化及分子生物学、组学等方法，结合显微成像追踪细胞动态行为、定量分析关键分子亚细胞定位和时空变化、数学建模等技术手段，探索动物发育的过程以及发育调控机制。

主要研究包括：

　　1.细胞周期、细胞形态与极性的调控机制及其与发育程序的偶联机理

　　2.Notch信号的调控机制

　　Lab of Cell and Tissue Dynamics

　　Metazoan development is the emergence of various cellular behaviors, including cell shape change, proliferation, adhesion, migration, and differentiation. These cellular behaviors are precisely regulated during development to drive tissue morphogenesis through the collective cell behaviors and, thus, successful embryogenesis. Using Drosophila and other animals as a model organism, we focus on cell and tissue dynamics to uncover the mechanisms driving tissue morphogenesis and embryonic development by addressing these key questions.

　　1. How are the cell cycle, cell shape and polarity controlled to coordinate the embryonic developmental programming?

　　2. How is Notch signaling regulated?

吕志一　副教授 博士生导师

E-mail：lvzhiyi@ouc.edu.cn

Tel：0532-82031732

博士生：

2022级：刘斌

2024级：杨慧清，许乐谣

硕士生：

2022级：姜清天，刘王芳

2023级：陈仰玉，张嫄梳，蒋秉谚

2024级：莫子华，王宇童，卢慧莹

承担课题：

　　中国海洋大学“青年英才工程”启动经费

　　山东省泰山学者“青年专家”经费

　　国家自然科学基金面上项目

讲授课程：

　　本科生课程：

　　《结构生物化学》理论（双语，32课时，2学分，秋季学期，海德学院；吕志一，独立讲授）

　　《定量生物学》理论（双语，32课时，2学分，春季学期，海洋生命学院；吕志一，独立讲授）

　　研究生课程

　　《学术论文写作》与《论文写作指导》，图像处理部分，吕志一，讲授。

2024年：

张临杰；崔海涛；李泳洁；郭雅倩；吕志一。基于顶点动力学模型的果蝇胚胎背部闭合过程模拟。数值计算与计算机应用, 2024, 45(3)

2023年：

李秋月; 张兆轩; 吕志一。果蝇羊浆膜细胞形态发生所需的Rho信号通路组分的RNAi筛选。中国细胞生物学学报, 2023, 45(7): 997-1008

王国庆; 尹传淏; 吕志一。果蝇合胞体胚胎中微丝和微管的动态调控。中国细胞生物学学报, 2023, 45(9): 1382-1389

2022年：

Y. Fu#, Z. Lv#, D. Kong, Y. Fan, B. Dong* (2022). High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6. Cell Proliferation 55 (7), e13257.

Z. Lv, N. Zhang, X. Zhang, J. Großhans, D. Kong* (2022).  The lateral epidermis actively counteracts pulling by the amnioserosa during dorsal closure. Frontiers in Cell and Developmental Biology 10:865397.

2021年：

Schmidt, A.#, L. Li#, Z. Lv, S. Yan and J. Grosshans* (2021). Dia- and Rok-dependent enrichment of capping proteins in a cortical region. J Cell Sci 134(21).

Zhao, L.#, F. Gao#, S. Gao#, Y. Liang#, H. Long#, Z. Lv#, Y. Su#, N. Ye#, L. Zhang#, C. Zhao#, X. Wang, W. Song*, S. Zhang* and B. Dong* (2021). Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms. Sci China Life Sci 64(8): 1236-1280.

Lv, Z., J. de-Carvalho, I. A. Telley and J. Grosshans*(2021). Cytoskeletal mechanics and dynamics in the Drosophila syncytial embryo. J Cell Sci 134(4).

2020年：

Lv, Z.*, J. Rosenbaum, S. Mohr, X. Zhang, D. Kong, H. Preiss, S. Kruss, K. Alim, T. Aspelmeier and J. Grosshans* (2020). The Emergent Yo-yo Movement of Nuclei Driven by Cytoskeletal Remodeling in Pseudo-synchronous Mitotic Cycles. Curr Biol 30(13): 2564-2573 e2565.

Lu, Q., Y. Gao, Y. Fu, H. Peng, W. Shi, B. Li, Z. Lv, X.-Q. Feng and B. Dong (2020). Ciona embryonic tail bending is driven by asymmetrical notochord contractility and coordinated by epithelial proliferation. Development 147(24): dev185868.

Selvaggio, G., A. Chizhik, R. Nissler, L. Kuhlemann, D. Meyer, L. Vuong, H. Preiss, N. Herrmann, F. A. Mann, Z. Lv, T. A. Oswald, A. Spreinat, L. Erpenbeck, J. Grosshans, V. Karius, A. Janshoff, J. Pablo Giraldo and S. Kruss (2020). Exfoliated near infrared fluorescent silicate nanosheets for (bio)photonics. Nat Commun 11(1): 1495.

2019年：

Kong, D*., Z. Lv, M. Haring, B. Lin, F. Wolf and J. Grosshans (2019). In vivo optochemical control of cell contractility at single-cell resolution. EMBO Rep 20(12): e47755.

Lv, Z., Q. Lu and B. Dong* (2019). Morphogenesis: a focus on marine invertebrates. Marine Life Science & Technology 1(1): 28-40.

Mann, F. A., Z. Lv, J. Grosshans, F. Opazo and S. Kruss (2019). Nanobody-Conjugated Nanotubes for Targeted Near-Infrared In Vivo Imaging and Sensing. Angew Chem Int Ed Engl 58(33): 11469-11473.

2018年之前：

Lv, Z., J. Rosenbaum, T. Aspelmeier and J. Grosshans* (2018). A 'molecular guillotine' reveals the interphase function of Kinesin-5. J Cell Sci 131(3).

Kaiser, F., Z. Lv, D. Marques Rodrigues, J. Rosenbaum, T. Aspelmeier, J. Grosshans and K. Alim *(2018). Mechanical Model of Nuclei Ordering in Drosophila Embryos Reveals Dilution of Stochastic Forces. Biophys J 114(7): 1730-1740.

Schmidt, A.#, Z. Lv# and J. Grosshans* (2018). ELMO and Sponge specify subapical restriction of Canoe and formation of the subapical domain in early Drosophila embryos. Development 145(2).

Lv, Z. and J. Grosshans *(2016). A Radial Actin Network in Apical Constriction. Dev Cell 39(3): 280-282.

Winkler, F.#, M. Gummalla#, L. Kunneke#, Z. Lv, A. Zippelius, T. Aspelmeier and J. Grosshans* (2015). Fluctuation Analysis of Centrosomes Reveals a Cortical Function of Kinesin-1. Biophys J 109(5): 856-868.

Yan, S.#, Z. Lv#, M. Winterhoff#, C. Wenzl, T. Zobel, J. Faix, S. Bogdan and J. Grosshans* (2013). The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization. J Cell Sci 126(Pt 8): 1796-1805.