水生生物有最古老的进化起源和最广泛的生境分布，形成了独特的生命特征和适应机制。水生生物资源也是人类重要的食物蛋白来源和渔业发展的物质基础。如何开发整合组学技术、高效挖掘组学信息、破解水生生物组学特征、解析繁殖发育等遗传调控机制，已成为进化发育和遗传育种等领域共同关注的焦点科学问题。

　　围绕上述问题，实验室主要从事水生生物基因组特征与重要性状解析研究，代表性成果包括：1) 建立了复杂基因组组装与扫描技术；绘制贝类等9个物种基因组图谱；2) 揭示了鱼类、贝类同形性染色体演化与性别决定机制：在斑点叉尾鮰上首次组装出水生动物完整Y染色体；发现扇贝具有动物界最古老同形性染色体，解析了其3.5亿年不分化的稳态机制；3) 解析了水生生物复杂性状的遗传基础：揭示了鱼类鳞片发生机制和海参皂苷合成机制。上述成果发表在Nature Cancer, Nature Ecology & Evolution, Nature Communications, Cell Discovery等国际高端期刊上。

包立随    教授 博士生导师

中国海洋大学“青年英才工程”第一层次教授

E-mail: baolisui@ouc.edu.cn

Tel：0532-85906585

教育背景：

2005年9月-2009年6月，中国海洋大学，生物技术，本科；

2005年9月-2009年6月，中国海洋大学，计算机科学与技术，本科；

2011年9月-2017年8月，美国奥本大学，水生生物基因组学，博士；  

科研工作经历：

2017年9月-2020年12月，美国芝加哥大学Ben May癌症研究中心，博士后；

2021年7月-2023年8月，中国海洋大学，海洋生物多样性与进化研究所，副教授；

2023年9月-至今，中国海洋大学，海洋生物多样性与进化研究所，教授。

研究方向和研究成果：

主要研究方向为围绕重要水生生物，开发复杂基因组组装与扫描的新技术，解析水生生物的性染色体演化、性别决定等适应性机制。主要论文以第一或通讯作者发表在Nature Cancer, Nature Ecology & Evolution, Nature Communications, Cell Discovery等国际高水平期刊上。

Prof. Lisui Bao 

Education:

2005.09-2009.06 B.A. in Biotechnology, Ocean University of China, China.

2005.09-2009.06 B.A. in Computer Science and Technology, Ocean University of China, China.

2011.09-2017.08 Ph.D. in Aquaculture Genomics, Auburn University, USA. 

Academic appointments：

2017.9-2020.12 Postdoctoral scholar in The Ben May Department for Cancer Research of The University of Chicago, USA.  

2021.7-2023.9 Associate professor of Ocean University of China.

Research focus: 

We develop new computational methods to integrate the large scale genomic, transcriptomic, and epigenetic data to understand the mechanisms of evolutionary adaptation, sex determination and chromosomal rearrangement.

Publications:  

# 代表共同第一作者

*代表共同通讯作者  

1. Bao Lisui, Zhong Xiaoming, Yang Yang, Yang Lixing^*. Starfish infers signatures of complex genomic rearrangements across human cancers. Nature Cancer (2022) 10.1038/s43018-022-00404-y

2. Han Wentao^#, Liu Liangjie^#, Wang Jing^#, Wei Huilan^#, Li Yuli^#, Zhang Lijing^#, Guo Zhenyi, Li Yajuan, Liu Tian, Zeng Qifan, Xing Qiang, Shu Ya, Wang Tong, Yang Yaxin, Zhang Meiwei, Li Ruojiao, Yu Jiachen, Pu Zhongqi, Lv Jia, Lian Shanshan, Hu Jingjie, Hu Xiaoli, Bao Zhenmin, Bao Lisui^*, Zhang Lingling^*, Wang Shi^*. Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation. Nature Ecology & Evolution (2022) 10.1038/s41559-022-01898-6

3. Bao Lisui, Tian Changxu, Liu Shikai, Zhang Yu, Elaswad Ahmed, Yuan Zihao, Khalil Karim, Sun Fanyue, Yang Yujia, Zhou Tao, Li Ning, Tan Suxu, Zeng Qifan, Liu Yang, Li Yueru, Li Yun, Gao Dongya, Dunham Rex, Davis Kenneth, Waldbieser Geoffrey, Liu Zhanjiang^*. The Y chromosome sequence of the channel catfish suggests novel sex determination mechanisms in teleost fish. BMC Biology (2019) 17(1):6

4. Wang Hao^#, Lv Jia^#, Zeng Qifan^*, Liu Yaran, Xing Qiang, Wang Shi, Hu Jingjie, Bao Lisui^*. Genetic differentiation and selection signatures in two bay scallop (Argopecten irradians) breeds revealed by whole-genome resequencing analysis. Aquaculture (2021) 543:736944（期刊论文）

5. Zeng Qifan^#, Liu Jing^#, Wang Chunde^#, Wang Hao, Zhang Lingling, Hu Jingjie, Bao Lisui^*, Wang Shi^*. High-quality reannotation of the king scallop genome reveals no 'gene-rich' feature and evolution of toxin resistance. Computational and Structural Biotechnology Journal (2021) 19:4954-4960

6. Dai Xiaoting^#, Zhu Xuan^#, Bao Lisui^#, Chen Xiaomei, Miao Yan, Li Yangping, Li Yuli, Lv Jia, Zhang Lingling, Huang Xiaoting, Bao Zhenmin, Wang Shi^*, Wang Jing^*. Decoding the byssus fabrication by spatiotemporal secretome analysis of scallop foot. Computational and Structural Biotechnology Journal (2022) 20:2713-2722

7. He Yan^#, Chang Yue^#, Bao Lisui^#, Yu Mengjun^#, Li Rui^#, Niu Jingjing, Fan Guangyi, Song Weihao, Seim Inge, Qin Yating, Li Xuemei, Liu Jinxiang, Kong Xiangfu, Peng Meiting, Sun Minmin, Wang Mengya, Qu Jiangbo, Wang Xuangang, Liu Xiaobing, Wu Xiaolong, Zhao Xi, Wang Xuliang, Zhang Yaolei, Guo Jiao, Liu Yang, Liu Kaiqiang, Wang Yilin, Zhang He, Liu Longqi, Wang Mingyue, Yu Haiyang, Wang Xubo, Cheng Jie, Wang Zhigang, Xu Xun, Wang Jian, Yang Huanming, Lee Simon Ming-Yuen, Liu Xin^*, Zhang Quanqi^*, Qi Jie^*. A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth. Molecular Ecology Resources (2019) 19(5):1309-1321

8. Li Yuli^#, Wang Ruijia^#, Xun Xiaogang^#, Wang Jing^#, Bao Lisui^#, Thimmappa Ramesha^#, Ding Jun^#, Jiang Jingwei^#, Zhang Liheng, Li Tianqi, Lv Jia, Mu Chuang, Hu Xiaoli, Zhang Lingling, Liu Jing, Li Yuqiang, Yao Lijie, Jiao Wenqian, Wang Yangfan, Lian Shanshan, Zhao Zelong, Zhan Yaoyao, Huang Xiaoting, Liao Huan, Wang Jia, Sun Hongzhen, Mi Xue, Xia Yu, Xing Qiang, Lu Wei, Osbourn Anne, Zhou Zunchun^*, Chang Yaqing^*, Bao Zhenmin^*, Wang Shi^*. Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation. Cell Discovery (2018) 4:29

9. Liu Zhanjiang^#*, Liu Shikai^#, Yao Jun^#, Bao Lisui^#, Zhang Jiaren^#, Li Yun^#, Jiang Chen, Sun Luyang, Wang Ruijia, Zhang Yu, Zhou Tao, Zeng Qifan, Fu Qiang, Gao Sen, Li Ning, Koren Sergey, Jiang Yanliang, Zimin Aleksey, Xu Peng, Phillippy Adam M., Geng Xin, Song Lin, Sun Fanyue, Li Chao, Wang Xiaozhu, Chen Ailu, Jin Yulin, Yuan Zihao, Yang Yujia, Tan Suxu, Peatman Eric, Lu Jianguo, Qin Zhenkui, Dunham Rex, Li Zhaoxia, Sonstegard Tad, Feng Jianbin, Danzmann Roy G., Schroeder Steven, Scheffler Brian, Duke Mary V., Ballard Linda, Kucuktas Huseyin, Kaltenboeck Ludmilla, Liu Haixia, Armbruster Jonathan, Xie Yangjie, Kirby Mona L., Tian Yi, Flanagan Mary Elizabeth, Mu Weijie, Waldbieser Geoffrey C. The channel catfish genome sequence provides insights into the evolution of scale formation in teleosts. Nature Communications (2016) 7:11757

10. Wang Ruijia^#, Sun Luyang^#, Bao Lisui^#, Zhang Jiaren, Jiang Yanliang, Yao Jun, Song Lin, Feng Jianbin, Liu Shikai, Liu Zhanjiang^*. Bulk segregant RNA-seq reveals expression and positional candidate genes and allele-specific expression for disease resistance against enteric septicemia of catfish. BMC Genomics (2013) 14:929

“十四五”国家重点研发计划课题（2022-2026）

国家自然科学基金面上项目（2023-2026）

国家自然科学基金青年项目（2022-2024）

山东省自然科学基金“杰青”项目（2025-2027）

山东省自然科学基金“优青”项目（海外）（2023-2025）

山东省“泰山学者”青年专家计划（2022-2025）

(#共同第一，*共同通讯)

1. Bao Lisui, Zhong Xiaoming, Yang Yang, Yang Lixing^*. Starfish infers signatures of complex genomic rearrangements across human cancers. Nature Cancer (2022) 10.1038/s43018-022-00404-y

2. Han Wentao^#, Liu Liangjie^#, Wang Jing^#, Wei Huilan^#, Li Yuli^#, Zhang Lijing^#, Guo Zhenyi, Li Yajuan, Liu Tian, Zeng Qifan, Xing Qiang, Shu Ya, Wang Tong, Yang Yaxin, Zhang Meiwei, Li Ruojiao, Yu Jiachen, Pu Zhongqi, Lv Jia, Lian Shanshan, Hu Jingjie, Hu Xiaoli, Bao Zhenmin, Bao Lisui^*, Zhang Lingling^*, Wang Shi^*. Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation. Nature Ecology & Evolution (2022) 10.1038/s41559-022-01898-6

3. Bao Lisui, Tian Changxu, Liu Shikai, Zhang Yu, Elaswad Ahmed, Yuan Zihao, Khalil Karim, Sun Fanyue, Yang Yujia, Zhou Tao, Li Ning, Tan Suxu, Zeng Qifan, Liu Yang, Li Yueru, Li Yun, Gao Dongya, Dunham Rex, Davis Kenneth, Waldbieser Geoffrey, Liu Zhanjiang^*. The Y chromosome sequence of the channel catfish suggests novel sex determination mechanisms in teleost fish. BMC Biology (2019) 17(1):6

4. Wang Hao^#, Lv Jia^#, Zeng Qifan^*, Liu Yaran, Xing Qiang, Wang Shi, Hu Jingjie, Bao Lisui^*. Genetic differentiation and selection signatures in two bay scallop (Argopecten irradians) breeds revealed by whole-genome resequencing analysis. Aquaculture (2021) 543:736944（期刊论文）

5. Zeng Qifan^#, Liu Jing^#, Wang Chunde^#, Wang Hao, Zhang Lingling, Hu Jingjie, Bao Lisui^*, Wang Shi^*. High-quality reannotation of the king scallop genome reveals no 'gene-rich' feature and evolution of toxin resistance. Computational and Structural Biotechnology Journal (2021) 19:4954-4960

6. Dai Xiaoting^#, Zhu Xuan^#, Bao Lisui^#, Chen Xiaomei, Miao Yan, Li Yangping, Li Yuli, Lv Jia, Zhang Lingling, Huang Xiaoting, Bao Zhenmin, Wang Shi^*, Wang Jing^*. Decoding the byssus fabrication by spatiotemporal secretome analysis of scallop foot. Computational and Structural Biotechnology Journal (2022) 20:2713-2722

7. He Yan^#, Chang Yue^#, Bao Lisui^#, Yu Mengjun^#, Li Rui^#, Niu Jingjing, Fan Guangyi, Song Weihao, Seim Inge, Qin Yating, Li Xuemei, Liu Jinxiang, Kong Xiangfu, Peng Meiting, Sun Minmin, Wang Mengya, Qu Jiangbo, Wang Xuangang, Liu Xiaobing, Wu Xiaolong, Zhao Xi, Wang Xuliang, Zhang Yaolei, Guo Jiao, Liu Yang, Liu Kaiqiang, Wang Yilin, Zhang He, Liu Longqi, Wang Mingyue, Yu Haiyang, Wang Xubo, Cheng Jie, Wang Zhigang, Xu Xun, Wang Jian, Yang Huanming, Lee Simon Ming-Yuen, Liu Xin^*, Zhang Quanqi^*, Qi Jie^*. A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth. Molecular Ecology Resources (2019) 19(5):1309-1321

8. Li Yuli^#, Wang Ruijia^#, Xun Xiaogang^#, Wang Jing^#, Bao Lisui^#, Thimmappa Ramesha^#, Ding Jun^#, Jiang Jingwei^#, Zhang Liheng, Li Tianqi, Lv Jia, Mu Chuang, Hu Xiaoli, Zhang Lingling, Liu Jing, Li Yuqiang, Yao Lijie, Jiao Wenqian, Wang Yangfan, Lian Shanshan, Zhao Zelong, Zhan Yaoyao, Huang Xiaoting, Liao Huan, Wang Jia, Sun Hongzhen, Mi Xue, Xia Yu, Xing Qiang, Lu Wei, Osbourn Anne, Zhou Zunchun^*, Chang Yaqing^*, Bao Zhenmin^*, Wang Shi^*. Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation. Cell Discovery (2018) 4:29

9. Liu Zhanjiang^#*, Liu Shikai^#, Yao Jun^#, Bao Lisui^#, Zhang Jiaren^#, Li Yun^#, Jiang Chen, Sun Luyang, Wang Ruijia, Zhang Yu, Zhou Tao, Zeng Qifan, Fu Qiang, Gao Sen, Li Ning, Koren Sergey, Jiang Yanliang, Zimin Aleksey, Xu Peng, Phillippy Adam M., Geng Xin, Song Lin, Sun Fanyue, Li Chao, Wang Xiaozhu, Chen Ailu, Jin Yulin, Yuan Zihao, Yang Yujia, Tan Suxu, Peatman Eric, Lu Jianguo, Qin Zhenkui, Dunham Rex, Li Zhaoxia, Sonstegard Tad, Feng Jianbin, Danzmann Roy G., Schroeder Steven, Scheffler Brian, Duke Mary V., Ballard Linda, Kucuktas Huseyin, Kaltenboeck Ludmilla, Liu Haixia, Armbruster Jonathan, Xie Yangjie, Kirby Mona L., Tian Yi, Flanagan Mary Elizabeth, Mu Weijie, Waldbieser Geoffrey C. The channel catfish genome sequence provides insights into the evolution of scale formation in teleosts. Nature Communications (2016) 7:11757