动物胚胎发育和成体器官再生的过程包含了“细胞命运的决定”以及“相关形态结构构建”两个相对独立却相互影响的过程。细胞信号转导是细胞命运决定过程中关键的调控机制：靶细胞通过受体接收信号细胞分泌出来的配体分子，引发其胞内的信号级联反应，最终诱导该细胞向特定命运分化。在细胞命运决定的同时，细胞通过改变其行为，驱动组织层面上的变化，逐步形成预定的结构。

本实验室以果蝇和斑马鱼为主要模式生物，结合遗传学、组学、分子生物学、显微成像与定量分析等现代技术，系统研究Hedgehog、Notch、JNK等多种重要发育信号的相互交织决定细胞命运的分子机理，以及细胞命运决定之后的细胞行为驱动胚胎发育以及器官（心脏）再生的作用机理。

Animal embryonic development and organ regeneration are driven by the signaling network-controlled cell fate determination and cell-shape-based tissue morphogenesis.  The target cells receive ligand molecules secreted by the signaling cell, which triggers an intracellular signaling cascade that ultimately induces the cell to differentiate toward a specific fate. While the cell's fate is being determined, interactions between cell-cell contacts, remodeling of the cytoskeleton, together with the cell number control system, collectively define tissue morphology, gradually forming the intended structure. 

Using Drosophila and zebrafish as the main model organisms, our laboratory focuses on how the interwoven signaling pathways, such as Hedgehog, Notch, and JNK, control embryo development and organ (mainly heart) regeneration in terms of cell fate determination, and how cellular behavior drives tissue morphogenesis. 

·    崂山国家实验室科技创新项目子课题

·    国家自然科学基金面上/青年项目

·    山东省自然科学基金面上项目

·    中国海洋大学“筑峰人才工程”经费

·    中国海洋大学“青年英才工程”经费

本科生课程：

《细胞生物学》理论（40课时，2.5学分，春季学期，水产学院；赵龙，独立讲授）

《分子生物学》理论（双语，48课时，3学分，春季学期，海德学院；苏颖，与其他两位老师合讲）

《模式生物发育与进化》理论（32课时，2.5学分，春季学期，全校通识课；苏颖、赵龙，参与讲授）

研究生课程

《分子发育生物学进展》，苏颖、赵龙，参与讲授

《高级生物化学》，赵龙，参与讲授

2026

Lian S^#, Wang W^#, Liu Y^#, Lu M^#, Han W^#, Luo J^#, Zhang X^#, Pang Y^#, Li Y^# , Li Y, Dang X, Wang P, Qin Y, Tan N, Zhang F, Zhang J, Gao S, Zhang R, Guo L, Jiang L, Zhang P, Zhang Y, Qu Z, Pan S, Zhang Y, Hu N, Chen Y, Cao Y, Li W, Chen X, Shi J, Yang S, Li Y, Song Q, Bao L, Li Y, Liu X, Wang J, Zhang L, Li R, Y X, Yang T, Chen J, Li L, Zhang M, Li L, Zhang R, Li H, Gu YH, Xu X, Yang H, Bao Z, Burns CG, Burns CE, Kelly R, Wang J, Zhao Y, Su Y, Fan G, Liu Q*, Wang S*, Fei J*, Pan S*, Zhao L* (2026) Spatially resolved single-cell atlas reveals the macroevolutionary trajectory of animal hearts.

Science Sep 3, 393(6815):eadw0855.

Guo L^#, Tong B^#, Gao X^#, Jia X^#, Liu X^#, LI L, Xu M, Zhang Y, Wang J, Liu Q, Han K, Zhang R, Lin Z, He L, Du X, Qin Y, Song Y, Yuan Z, Liu X, Li Y, Luo J, Yang T, Chen J, Li Y, Wang X, Song Z, Seim I, Zhao L, Zhang B, Chen R, He B, Shao C, Yang H, Xun X, Sun F*, Qu Q*, Chen S*, Fan G* (2026) A cross-vertebrate single-cell and spatial atlas reveals evolutionary trajectories of gastrointestinal cellular innovation.

Cell Genomics Aug 18, 101335

Cheng X^#, Li L^#, Fang S, Yu L, Liu C, Jiao Y, Fang Y, Lin L, Zhao L*, Su Y* (2026) Mitochondrial protein Mrpl13 regulates zebrafish liver development through the mTORC1-mitochondrial homeostasis pathway.

Communications Biology Apr 30, 9(1):909.

Li L^#, Cheng X^#, Liu C, Fang S, Lin L, Su Y*, Zhao L* (2026) Mitochondrial protein Mrpl4 is required for zebrafish intestinal development.

FEBS LettersJun, 600(12):1756-1769.

Gan T^#, Su Q^#, Zhang Y, Zhao L*, Su Y* (2026) SUMO protease Pira induces autophagy-related cell death during Drosophila development.

GeneticsMarch 4, 232(3):iyaf277.

2025

Li L^#, Lu M^#, Guo L^#, Zhang X^#, Liu Q^#, Zhang M^#, Gao J, Xu M, Lu Y, Zhang F, Li Y, Zhang R, Liu X, Pan S, Zhang X, Li Z, Chen Y, Su X, Zhang N, Guo W, Yang T, Chen J, Qin Y, Zhang Z, Cui W, Yu L, Gu Y, Yang H, Xu X, Wang J, Burns CE, Burns CG, Han K*, Zhao L*, Fan G*, Su Y* (2025) An organ-wide spatiotemporal transcriptomic and cellular atlas of the regenerating zebrafish heart.

Nature CommunicationsApr 19, 16(1): 3716.

Xu D#, Pan J#, Zhang Y, Fang Y, Zhao L*, Su Y* (2025) RpS24 is required for meiotic divisions and spermatid differentiation during Drosophila spermatogenesis.

FASEB Journal 39(11):e70646.

Luo W#, Zhang F#, Zhao F, Fang Y, Zhao L*, Su Y*. (2025) Dual role of PpV in Drosophila crystal cell proliferation and survival.

Journal of Molecular Cell Biology Mar 21, 16(9): mjae028.

He J#, Fang Y#, Zhao L*, Su Y* (2025) ZnT35C maintains zinc homeostasis to regulate spermatogenesis in Drosophila testis.

Archives of Insect Biochemistry and Physiology 118(1):e70017.

2024

Fang Y^#, Zhang F^#, Zhao F, Wang J, Cheng X, Ye F, He J, Zhao L*, Su Y*. (2024) RpL38 modulates germ cell differentiation by controlling Bam expression in Drosophila testis.

Science China-Life Sciences67(11):2411-2425.

Zhang F^#, Luo W^#, Liu S^#, Zhao L*, Su Y*. (2024) Protein phosphatase 2A regulates blood cell proliferation and differentiation in Drosophila larval lymph glands.

FEBS Journal291(20):4558-4580.

Xu D, Pan J, Fang Y, Zhao L*, Su Y*. (2024) RpS25 is required for sperm elongation and individualization during Drosophila spermatogenesis.

Biochemical and Biophysical Research Communications 702:149633.

2023

Lu M^#, Hayat R^#, Zhang X^#, Jiao Y, Huang J, Huangfu Y, Jiang M, Fu J, Jiang Q, Gu Y, Wang S, Akerberg A, Su Y*, Zhao L*. (2023) Comparative analysis of the cardiac structure and transcriptome of scallop and snail, perspectives on heart chamber evolution.

Marine Life Science & Technology 5(4): 478-491.

Fang Y^#, Zhang F^#, Zhan Y^#, Lu M, Xu D, Wang J, Li Q, Zhao L*, Su Y*. (2023) RpS3 is required for spermatogenesis of Drosophila melanogaster.

Cells 12(4):573.

Zhang M^#, Liu C^#, Zhao L, Zhang X*, Su Y*. (2023) The emerging role of protein phosphatase in regeneration.

Life (Basel) 13(5):1216.

2022

Akerberg A, Trembley M, Butty V, Schwertner A, Zhao L, Beerens M, Liu X, Mahamdeh M, Yuan S, Boyer L, MacRae C, Nguyen C, Pu W, Burnes CE, Burns CG. (2022) RBPMS2 is a myocardial-enriched splicing regulator required for cardiac function.

Circulation Research Dec 2, 131(12):980-1000.

Luo W, Liu S, Zhang F, Zhao L*, Su Y*. (2022) Metabolic strategy of macrophages under homeostasis or immune stress in Drosophila.

Marine Life Science & Technology4(3): 291-302.

2021

Liu M^#, Liu A^#, Wang J^#, Zhang Y, Li Y, Su Y*, Zhu AJ*. (2021) Competition between two phosphatases fine-tunes Hedgehog signaling.

Journal of Cell Biology 220(2): e202010078.

Liu M^#, Su Y^#, Peng J, Zhu AJ*. (2021) Protein modifications in Hedgehog signaling: Cross talk and feedback regulation confer divergent Hedgehog signaling activity.

BioEssaysNov 5: e2100153.

Zhao L^#, Gao F ^#, Gao S ^#, Liang Y ^#, Long H ^#, Lv Z ^#, Su Y^#, Ye N ^#, Zhang L ^#, Zhao C ^#, Wang X, Song W*, Zhang S*, Dong B*. (2021) Biodiversity-based development and evolution: The emerging research systems in model and non-model organisms.

Science China-Life Sciences 64(8): 1236-1280.

Gao J, Fan L, Zhao L*, Su Y*. (2021) The interaction of Notch and Wnt signaling pathways in vertebrate regeneration.

Cell Regeneration 10(1): 11.

Gan T^#, Fan L^#, Zhao L, Misra M, Liu M, Zhang M*, Su Y*.(2021) JNK signaling in Drosophila aging and longevity.

International Journal of Molecular Sciences22(17): 9649.

2021年以前

Zhao L, Ben-Yair R, Burns CE*, Burns CG*. (2019) Endocardial Notch signaling promotes cardiomyocyte proliferation in the regenerating zebrafish heart through Wnt pathway antagonism. Cell Reports 26(3): 546-554.

Galvez-Santisteban M, Chen D, Zhang R, Serrano R, Nguyen C, Zhao L, Nerb L, Masutani EM, Vermot J, Burns CG, Burns CE, del Alamo JC, Chi NC. (2019) Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming. eLife8:e44816.

Chi C, Wang L, Lan W, Zhao L*, Su Y*. (2018) PpV, acting via the JNK pathway, represses apoptosis during normal development of Drosophila wing. Apoptosis23: 554-562.

Zhao L, Wang L, Chi C, Lan W, Su Y*. (2017) The emerging roles of phosphatases in Hedgehog pathway. Cell Communication and Signaling15: 35.

Han P, Bloomekatz J, Ren J, Zhang R, Grinstein JD, Zhao L, Burns CG, Burns CE, Anderson RM, and Chi NC. (2016) Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature534: 700-704.

Jahangiri L, Sharpe M, Novikov N, González-Rosa JM, Borikova A, Nevis K, Paffett-Lugassy N, Zhao L, Adams M, Guner-Ataman B, Burns CE, Burns CG. (2015) The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field. Development143: 113-122.

Mahmoud A, O’Meara C, Gemberling M, Zhao L, Bryant DM, Zheng RM, Gannon JB, Cai L, Choi WY, Egaczyk GF, Burns CG, Burns CE, Macrae CA, Poss KD, Lee RT. (2015) Nerves regulate cardiomyocyte proliferation and heart regeneration. Developmental Cell34: 387-399.

Jang IH, Lu YF, Zhao L, Wenzel PL, Kume T, Datta SM, Arora N, Guiu J, Lagha M, Kim PG, Schlaeger TM, Zon LI, Gigas A, Burns CE, Daley G. (2015) Notch1 acts via Foxc2 to induce the endothelial to hematopoietic transition during embryonic development. Blood125(9): 1418-1426.

Harrison M, Bussmann J, Huang Y, Zhao L, Osorio A, Burns CG, Burns CE, Sucov H, Siekmann A, Lien C. (2015) Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Developmental Cell33(4):442-454.

Zhao L, Borikova AL, Ben-Yair R, Guner-Ataman B, Macrae CA, Lee RT, Burns CG*, Burns CE*. (2014) Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. PNAS 111(4): 1403-1408.

Su Y^#, Ospina JK^#, Zhang J^#, Michelson A, Schoen AM, Zhu AJ*. (2011) Sequential phosphorylation of Smoothened transduces graded Hedgehog signaling. Science Signaling 4: ra43.

Zhao L^#, Zhao XY^#, Tian T^#, Lu QL, Nirma Skrbo-Larssen, Wu D, Kuang Z, Zheng XF, Han YC, Yang SY, Zhang CM, Meng AM*. (2008) Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovascular Research 80(2): 200-208.

Su Y^#, Zhang L^#, Gao X, Meng F, Wen J, Zhou H, Meng A*, Chen Y*. (2007) The evolutionally conserved activities of Dapper2 in antagonizing TGF-b signaling. FASEB Journal21: 682-690.

Lin X^#, Duan X^#, Liang Y^#, Su Y^#, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen Y, Meng A, Feng X*. (2006) PPM1A functions as a Smad phosphatase to terminate TGFb signaling.Cell125: 915-928.