形态发生与进化实验室
Laboratory for Morphogenesis & Evolution
Team Leader: Prof. Bo DONG
研究方向

    实验室的研究方向是动物组织器官发育的分子机制及细胞生物力学基础。以果蝇和海鞘等模式动物为材料,通过细胞遗传发育生物学技术手段,结合数学物理模型,研究囊泡极性运输、细胞骨架动态、胞外基质物理特性及其对细胞行为的影响等。 发现了脊索管腔形成的细胞学过程,揭示了调控细胞及器官形态发育变化的重要信号通路,建立了决定生物管腔几何形状的数学物理模型。研究结果相继发表在PNAS, Nature Communications, Cell Reports, PLOS Biology, Current Opinion in Genetics & Development, Development等国际主流杂志。                  


研究队伍



     

 董波 教授,博士生导师

 E-mail: bodong@ouc.edu.cn  

 Tel0532-82032733, 82032735

 Resume



   




 隗健凯 讲师,硕士生导师

 E-mail: weijiankai@ouc.edu.cn  

Tel0532-82032735

 Resume







 吕志一 副教授,硕士生导师

 E-mail: lvzhiyi@ouc.edu.cn  

Tel0532-82032732

 Resume





承担课题

· 国家自然科学基金面上项目
· 山东省自然科学基金项目
· 山东省泰山学者工程项目


近期论文及成果

· Hannezo E#, *,Dong B#, *, Recho P, Joanny JF, Hayashi S.A cortical instability drives periodic supracellular actin pattern formation in epithelial tubes.Proceedings of the National Academy of Sciences, 2015. 112 (28): 8620-8625. (#Co-first authors; *Corresponding authors) doi:10.1073/pnas.1504762112

Commentary in: Nir S. Gov, Saoirse S. McSharry, and Greg J. Beitel,Three-ring circus without a ringmaster: Self-organization of supracellular actin ring patterns during epithelial morphogenesis.PNAS,2015 112 (28) 8521-8522.

· 董波,海洋模式动物海鞘及其脊索发育与调控,科学通报,2015,60: 1167-1179.

· Denker E, Sehring I,Dong B, Audisso J, Mathiesen B, Jiang D.Regulation by a TGFβ-ROCK-actomyosin axis secures a non-linear lumen expansion that is essential for tubulogenesis.Development, 2015, 142: 1639-1650.

· Dong B, Hayashi S.Shaping of biological tubes by mechanical interaction of cell and extracellular matrix.Current Opinion in Genetics & Development, 2015, 32: 129-134.

· Dong B, Miao GX, Hayashi S.A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis inDrosophila.Development, 2014, 141(21): 4104-4109.

Selected as a highlight in this issue “Fat body shapes up the trachea”,  

http://dev.biologists.org/content/141/21/e2102?etoc

· Dong B*, Hannezo E, Hayashi S*.Balance between apical membrane growth and luminal matrix resistance determines the shape of epithelial tubule.Cell Reports2014, 7(4): 941-950. (*Corresponding authors).

· Sehring I‡,Dong B‡, Denker E, Deng W, Jiang D.An Equatorial Contractile Mechanism Drives Cell Elongation but not Cell Division.PLOS Biology, 2014, 12(2): e1001781. (‡Co-first authors)

Commentary in: A real stretch: mechanisms behind cell elongation. [PLoS Biol. 2014]http://www.ncbi.nlm.nih.gov/pubmed/24503562

· DongB, KakiharaK, Otani T, WadaH, Hayashi S.Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control.Nature Communications. 2013, 4, 1358.

· Dong B, Deng W, Jiang D,Distinct cytoskeleton populations and extensive crosstalk controlCiona notochord tubulogenesis.Development, 2011, 138 (8): 1631-1641.

Selected as a Recommended Read by Faculty of 1000.http://f1000.com/9601956

· Dong B, Horie T, Denker E, Kusakabe T, Tsuda M, Smith WC, Jiang D.Tube formation by complex cellular processes inCiona intestinalis notochord.Developmental Biology 2009, 330: 237-249.


其他