进化基因组学实验室 Laboratory of Evolutionary Genomics P.I.: Prof. Hongan LONG |
研究方向 以微生物为主要研究对象,利用组学、分子遗传学和细胞生物学方法,结合种群遗传学与微生物学理论,聚焦微生物的基因组突变以及行为的进化生物学研究,具体研究方向如下: A. 原生动物的表型可塑性与适应性演化; B. 海洋微生物的基因组进化以及稳定性机制; C. 微生物环境胁迫下的突变形成; D. 医疗及环境水体中病源微生物的抗药性演化; E. 原生动物生殖方式的调控与演化。 Research We are interested in microbial evolution, with a focus on mutation rate and behavior evolution. The research models are quite broad, including cilaites, bacteria, yeast, etc. Our research strategy combines population genetics theory, experimental evolution, -omics sequencing, genetic techniques, and bioinformatic tools. The lab deems the training of indepedent researchers as our first task and research as the second. Graduate students would get a complete training of scientific research and multiple undergrad assistants are provided for their research. We are now exploring the following topics: A. Phenotypic plasticity of ciliates, and its role in evolution; B. Genome instability and evolution of marine microbial organisms; C. Ecological dependence of mutation rate; D. Antibiotic resistance evolution of pathogens in medical and natural environments; E. Genetic regulation and evolution of reproduction in ciliates. 招聘/招生 招聘:协助拟加入人员申请中国海洋大学“青年英才工程”(http://rsc.ouc.edu.cn/04/50/c1485a66640/page.htm)等各层次人才计划;定期招收实验室管理、技术等科研助理岗位。 招生:常年招收优秀本科生兼职助理、硕士生、博士生和博士后。 具体信息请邮件咨询(longhongan@ouc.edu.cn) 实验室负责人 P.I. 龙红岸 教授 1982年8月出生 Hongan Long, Professor, Ph.D. E-mail: longhongan@ouc.edu.cn Tel: +86 532 8203 1723 承担课题 第15批国家“青千”(2019-2022) 山东省“泰山学者”青年项目(2019.1-2024.1) 国家自然科学基金面上项目(31872228; 2019.1-2022.12) 中央高校基本科研业务费(2018.1-2021.1) 中国海洋大学“筑峰人才计划”启动经费(2018.9-2021.8) Running Projects 'Taishan Scholar' grant for young scientists, Shandong Province (2019.1-2024.1) NSFC grant (No.31872228; 2019.1-2022.12; Phenotypic plasticity and its evolution in the ciliate Glauconema trihymene) Research grant from the Central Government of China (2018.1-2021.1) Startup grant from Ocean University of China (2018.9-2021.8) 近期代表性论文(*,corresponding author; #, co-first-author) Recent publications Full texts of publications can be downloaded from researchgate Long*, H.; Miller, S.F.; Williams, E.; Lynch, M. 2018. Specificity of the DNA mismatch repair system (MMR) and mutagenesis bias in bacteria. Molecular Biology and Evolution 35(10):2414–2421. Long, H.; Sung#, W.; Kucukyildirim#,S.; Williams,E.; Miller, S.;Guo, W.; Patterson, C.; Gregory, C.; Strauss, C.; Stone, C.; Berne, C.; Kysela, D.; Shoemaker, W.; Muscarella, M.; Luo, H.; Lennon, J.; Brun, Y.; Lynch*, M. 2018. Evolutionary determinants of genome-wide nucleotide composition. Nature Ecology and Evolution 2: 237-240. Strauss, C.; Long*, H.; Patterson, C.; Te,R.; Lynch, M. 2017. Genome-wide mutation rate response to pH change in the coral reef pathogen Vibrio shilonii AK1. mBio 8 (4): e01021-17 Long, H.; Miller, Samuel F; Strauss, Chloe; Zhao, Chaoxian; Cheng, Lei; Ye, Zhiqiang; Griffin, Katherine; Te, Ronald; Lee, Heewook; Chen, Chi-Chun; Lynch*, Michael. 2016. Antibiotic treatment enhances the genome-wide mutation rate of target cells. Proceedings of the National Academy of Sciences U.S.A. 113(18): E2498-E2505 Long*, H.; Kucukyildirim#, Sibel; Sung, Way; Williams, Emily; Lee, Heewook; Ackerman, Matthew; Doak, Thomas G; Tang, Haixu; Lynch, Michael. 2015. Background mutational features of the radiation-resistant bacterium Deinococcus radiodurans. Molecular Biology and Evolution 32(9): 2383-2392 Long*, H.; Sung, Way; Miller, Samuel F; Ackerman, Matthew S; Doak, Thomas G; Lynch, Michael. 2015. Mutation rate, spectrum, topology, and context-dependency in the DNA mismatch repair-deficient Pseudomonas fluorescens ATCC948. Genome Biology and Evolution 7(1): 262-271 Farlow*, Ashley; Long#, H.; Arnoux, Stéphanie; Sung, Way; Doak, Thomas G; Nordborg, Magnus; Lynch, Michael. 2015. The spontaneous mutation rate in the fission yeast Schizosaccharomyces pombe. Genetics 201(2):737-744 Long*, H.; Paixão, Tiago; Azevedo, Ricardo BR; Zufall, Rebecca A. 2013. Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophila. Genetics 195(2): 527-540 Long*, H.; Zufall, R.A. 2010. Diverse modes of reproduction in the marine free-living ciliate Glauconema trihymene. BMC Microbiology 10(1): 108 奖项 2018 李氏基金会杰出创新奖 2016 美国遗传学会DeLill Nasser遗传学职业发展奖 Awards 2018 Li Foundation Heritage Prize-Excellence in Creativity 2016 DeLill Nasser Award for Professional Development in Genetics, Genetics Society of America 实验室理念 Principles on graduate students training https://b.xiumi.us/stage/v5/2UmMG/133846096?from=timeline&isappinstalled=0#/ 实验室人员 People in the lab 科研助理:蒋婉月 研究生: 吴琨(2017级硕士研究生,拟直博),水生生物学专业,wukun@stu.ouc.edu.cn,研究方向:微生物的基因组突变规律与演化 潘娇(2017级硕士研究生,拟直博),水生生物学专业,panjiao@stu.ouc.edu.cn,研究方向:微生物的突变与行为演化 李海潮(2018级硕士研究生),水生生物学专业,lihaichao@stu.ouc.edu.cn,研究方向:真核微生物休眠调控与演化 林彤彤(2019级硕士研究生),生物学专业,lintongtong@stu.ouc.edu.cn,研究方向:待定 倪家豪(2019级硕士研究生),生物工程专业,nijiahao@stu.ouc.edu.cn,研究方向:待定 本科生: 2016级:姜昱建(生态学)、江安(生物科学)、周霞(生物科学)、范效楷(渔业资源)、崔潇(生物科学)、冯一(海洋渔业)、郭慧琳(渔业资源)、张雯露(生物科学)、王钰瑾(生态学)、赵丹歌(生物技术)、吴晓琳(生物技术) 2017级:邓子光(生物科学)、何文斌(生物科学)、兰烨琳(海洋渔业)、张雅凡(生物技术)、张帆(生物技术) 2018级:韩玉敏(水产养殖)、邱文燕(水产养殖)、迟润达(水产养殖)、冯若冰(生物技术)、韩雨杉(水产养殖)、刘明港(水产养殖) 其它: 业余创作教育题材小说《转变 第一部》: 链接:https://pan.baidu.com/s/1PTtD1JZBWlVapdHXC50Rgg 提取码:e0qv |