进化基因组学实验室
Laboratory of Evolutionary Genomics
P.I.: Prof. Hongan LONG



研究方向

以微生物为主要研究对象,利用组学、分子遗传学和细胞生物学方法,结合种群遗传学与微生物学理论,聚焦微生物的基因组突变以及行为的进化生物学研究,具体研究方向如下:

A. 原生动物的表型可塑性与适应性演化;

B. 海洋微生物的基因组进化以及稳定性机制;

C. 微生物环境胁迫下的突变形成;

D. 医疗及环境水体中病源微生物的抗药性演化;

E. 原生动物生殖方式的调控与演化。  


Research

We are interested in microbial evolution, with a focus on mutation rate and behavior evolution. The research models are quite broad, including cilaites, bacteria, yeast, etc. Our research strategy combines population genetics theory, experimental evolution, -omics sequencing, genetic techniques, and bioinformatic tools. The lab deems the training of indepedent researchers as our first task and research as the second. Graduate students would get a complete training of scientific research and multiple undergrad assistants are provided for their research. We are now exploring the following topics:

A. Phenotypic plasticity of ciliates, and its role in evolution;

B. Genome instability and evolution of marine microbial organisms;

C. Ecological dependence of mutation rate;

D. Antibiotic resistance evolution of pathogens in medical and natural environments;

E. Genetic regulation and evolution of reproduction in ciliates.


招聘/招生

招聘:协助拟加入人员申请中国海洋大学“青年英才工程”(http://rsc.ouc.edu.cn/04/50/c1485a66640/page.htm)等各层次人才计划;定期招收实验室管理、技术等科研助理岗位。

招生:常年招收优秀本科生兼职助理、硕士生、博士生和博士后。

具体信息请邮件咨询(longhongan@ouc.edu.cn)


实验室负责人

P.I.

龙红岸 山东省汶上县人,,博士生导

1982年8月出生 

Hongan Long, Professor, Ph.D.

E-mail: longhongan@ouc.edu.cn  

Tel: +86 532 8203 1723

简历 Resume


承担课题

第15批国家“青千”(2019-2022)

山东省“泰山学者”青年项目(2019.1-2024.1)

国家自然科学基金面上项目(31872228; 2019.1-2022.12)

中央高校基本科研业务费(2018.1-2021.1)

中国海洋大学“筑峰人才计划”启动经费(2018.9-2021.8) 


Running Projects

'Taishan Scholar' grant for young scientists, Shandong Province (2019.1-2024.1)

NSFC grant (No.31872228; 2019.1-2022.12; Phenotypic plasticity and its evolution in the ciliate Glauconema trihymene)

Research grant from the Central Government of China (2018.1-2021.1)

Startup grant from Ocean University of China (2018.9-2021.8)


近期代表性论文(*,corresponding author; #, co-first-author)

Recent publications

Full texts of publications can be downloaded from researchgate

Long*, H.; Miller, S.F.; Williams, E.; Lynch, M. 2018. Specificity of the DNA mismatch repair system (MMR) and mutagenesis bias in bacteria. Molecular Biology and Evolution 35(10):2414–2421.    

Long, H.; Sung#, W.; Kucukyildirim#,S.; Williams,E.; Miller, S.;Guo, W.; Patterson, C.; Gregory, C.; Strauss, C.; Stone, C.; Berne, C.; Kysela, D.; Shoemaker, W.; Muscarella, M.; Luo, H.; Lennon, J.; Brun, Y.; Lynch*, M. 2018. Evolutionary determinants of genome-wide nucleotide composition. Nature Ecology and Evolution 2: 237-240.  

Strauss, C.; Long*, H.; Patterson, C.; Te,R.; Lynch, M. 2017. Genome-wide mutation rate response to pH change in the coral reef pathogen Vibrio shilonii AK1. mBio 8 (4): e01021-17  

Long, H.; Miller, Samuel F; Strauss, Chloe; Zhao, Chaoxian; Cheng, Lei; Ye, Zhiqiang; Griffin, Katherine; Te, Ronald; Lee, Heewook; Chen, Chi-Chun; Lynch*, Michael. 2016. Antibiotic treatment enhances the genome-wide mutation rate of target cells. Proceedings of the National Academy of Sciences U.S.A. 113(18): E2498-E2505  

Long*, H.; Kucukyildirim#, Sibel; Sung, Way; Williams, Emily; Lee, Heewook; Ackerman, Matthew; Doak, Thomas G; Tang, Haixu; Lynch, Michael. 2015. Background mutational features of the radiation-resistant bacterium Deinococcus radiodurans. Molecular Biology and Evolution 32(9): 2383-2392 

Long*, H.; Sung, Way; Miller, Samuel F; Ackerman, Matthew S; Doak, Thomas G; Lynch, Michael. 2015. Mutation rate, spectrum, topology, and context-dependency in the DNA mismatch repair-deficient Pseudomonas fluorescens ATCC948. Genome Biology and Evolution 7(1): 262-271 

Farlow*, Ashley; Long#, H.; Arnoux, Stéphanie; Sung, Way; Doak, Thomas G; Nordborg, Magnus; Lynch, Michael. 2015. The spontaneous mutation rate in the fission yeast Schizosaccharomyces pombe. Genetics 201(2):737-744 

Long*, H.; Paixão, Tiago; Azevedo, Ricardo BR; Zufall, Rebecca A. 2013. Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophila. Genetics 195(2): 527-540 

Long*, H.; Zufall, R.A. 2010. Diverse modes of reproduction in the marine free-living ciliate Glauconema trihymene. BMC Microbiology 10(1): 108


奖项

2018 李氏基金会杰出创新奖

2016 美国遗传学会DeLill Nasser遗传学职业发展奖


Awards

2018 Li Foundation Heritage Prize-Excellence in Creativity

2016 DeLill Nasser Award for Professional Development in Genetics, Genetics Society of America


实验室理念

Principles on graduate students training

https://b.xiumi.us/stage/v5/2UmMG/133846096?from=timeline&isappinstalled=0#/


实验室人员

People in the lab

科研助理:蒋婉月

研究生:

吴琨(2017级硕士研究生,拟直博),水生生物学专业,wukun@stu.ouc.edu.cn,研究方向:微生物的基因组突变规律与演化

潘娇(2017级硕士研究生,拟直博),水生生物学专业,panjiao@stu.ouc.edu.cn,研究方向:微生物的突变与行为演化

李海潮(2018级硕士研究生),水生生物学专业,lihaichao@stu.ouc.edu.cn,研究方向:真核微生物休眠调控与演化

林彤彤(2019级硕士研究生),生物学专业,lintongtong@stu.ouc.edu.cn,研究方向:待定

倪家豪(2019级硕士研究生),生物工程专业,nijiahao@stu.ouc.edu.cn,研究方向:待定

本科生:

2016级:姜昱建(生态学)、江安(生物科学)、周霞(生物科学)、范效楷(渔业资源)、崔潇(生物科学)、冯一(海洋渔业)、郭慧琳(渔业资源)、张雯露(生物科学)、王钰瑾(生态学)、赵丹歌(生物技术)、吴晓琳(生物技术)

2017级:邓子光(生物科学)、何文斌(生物科学)、兰烨琳(海洋渔业)、张雅凡(生物技术)、张帆(生物技术)

2018级:韩玉敏(水产养殖)、邱文燕(水产养殖)、迟润达(水产养殖)、冯若冰(生物技术)、韩雨杉(水产养殖)、刘明港(水产养殖)


其它:

业余创作教育题材小说《转变 第一部》:

链接:https://pan.baidu.com/s/1PTtD1JZBWlVapdHXC50Rgg 

提取码:e0qv