海洋生物遗传学实验室
Laboratory of Genetics of Marine Organisms
Team Leader: Prof. Guanpin YANG
研究方向

藻类遗传学和遗传改良:围绕海带和养殖微藻,开展经济性状的遗传基础解析和抗逆抗病生理遗传基础研究,培育杂交海带、海带杂交品种和养殖微藻品种,为海藻养殖产业持续发展提供技术和材料保障。主要成果有杂交海带、海带杂交品种培育及种性维持策略研发;海带高密度连锁图谱绘制;微藻基因组测序和抗逆生理遗传基础解析等。(2)海水养殖动物免疫学与病害控制:开展鲆鲽类模式识别受体、接头蛋白、干扰素调节因子、干扰素、效应分子等的分子结构、转录调节、免疫应答表达模式、抗病毒活性及相关信号通路与免疫调控网络研究,揭示水产动物抗病免疫机制。已在鱼类抗病毒天然免疫分子基础与调控网络研究上形成了明显优势和特色,相关论文受到国内外同行广泛关注。主要成果有:分离了近30个病原识别、信号转导与免疫效应等过程的基因;揭示了LRR数量对TLRs配体识别方式的影响,阐明了配体诱导tlrs表达的机制,并建立了配体-TLR调控网络模型;发现了tlr22基因的进化规律,提出tlr22基因内含子发生模式;阐明了irf基因受病毒两轮诱导表达的调控规律,发现了鱼类IRF3在干扰素抗病毒反应中的主导作用。(3)海藻-细菌相互作用、海藻入侵的分子机制及大型经济海藻的生活史研究:探索大型经济海藻致病菌/致病因子及海藻免疫防御反应机制和海藻入侵分子机制、解析大型经济海藻的生活史,为建立海藻种苗繁育技术提供理论支持,为海藻高值化利用及海藻养殖品种多样化提供种质资源。与德国、英国和法国等国的多个实验室建立了紧密合作关系


研究队伍                     

 

     

 杨官品 教授,博士生导

 E-mail: yguanpin@ouc.edu.cn  

Tel: 132 0641 2039

Resume


 

  




 胡国斌 教授,博士生导

 E-mail: huguobin@ouc.edu.cn  

Tel: 8203 2583

Resume







 王高歌 教授,博士生导

 E-mail: wgaoge@ouc.edu.cn  

Tel: 8203 1809

Resume






承担课题

与研究内容(1)相关的有自然科学基金1项、863项目1项;与研究内容(2)相关的有国家自然科学基金2项、海洋公益性行业科研专项1项、山东省自然科学基金1项;与研究内容(3)相关的有国家自然基金1项、国家中德科学交流中心项目1项、国家海洋局海洋公益性项目子课题1项目、青岛市应用基础研究项目1项、德国教研部资助课题1项

  

近期论文及成果

Li X, Zhang Z, Qu S, Liang G, Sun J, Zhao N, Cui C, Cao Z, Li Y, Pan J, Yu S, Wang Q, Li X, Luo S, Song S, Guo L, Yang G*. 2016. Improving seedless kelp (Saccharina japonica) during its domestication by hybridizing gametophytes and seedling-raising from sporophytes. Scientific Reports 6: 21255.

Li X, Zhang Z, Qu S, Liang G, Zhao N, Sun J, Song S, Cao Z, Li X, Pan J, Luo S, Zhang L, Cui C, Peng J, Li Y, Wu R, Zhao J, Qian R, Wang L, Sai S, Yang G*. 2016. Breeding of an intraspecific kelp hybrid Dongfang no. 6 (Saccharina japonica, Phaeophyceae, Laminariales) for suitable processing products and evaluation of its culture performance. Journal of Applied Phycology. 28 439-447.

Zhang N, Zhang L, Tao Y, Guo L, Sun J, Li X, Zhao N, Peng J, Li X, Zeng L, Chen J, Yang G*. 2015. Construction of a high density SNP linkage map of kelp (Saccharina japonica) by sequencing Taq I site associated DNA and mapping of a sex determining locus. BMC Genomics 16: 189.

Li S, Wang G, Liu D, Liu Q, Hu G*. Cloning and expression analysis of a Toll-like receptor 21 (TLR21) gene from turbot, Scophthalmus maximus. Developmental and Comparative Immunology, 2017, 73:163-168.

Zhang H, Hu G*, Liu Q, Zhang S. Cloning and expression study of a Toll-like receptor 2 (tlr2) gene from turbot, Scophthalmus maximus. Fish & Shellfish Immunology, 2016, 59:137-148.

Liu D, Chen J, Zhang H, Hu M, Lou H, Liu Q, Zhang S, Hu G*. Interferon regulatory factor 4b (IRF4b) in Japanese flounder, Paralichthys olivaceus: Sequencing, ubiquitous tissue distribution and inducible expression by poly(I:C) and DNA virus. Developmental and Comparative Immunology, 2016, 62:127-133.

Lin JY, Hu GB*, Liu DH, Li S, Liu QM, Zhang SC. Molecular cloning and expression analysis of interferon stimulated gene 15 (ISG15) in turbot, Scophthalmus maximus. Fish & Shellfish Immunology, 2015, 45(2):895-900.

Hu GB*, Li XP, Liu DH, Liu QM, Zhang SC. A Toll-like receptor 3 homolog that is up-regulated by poly I:C and DNA virus in turbot, Scophthalmus maximus. Journal of Fish Biology, 2015, 86(2): 431-447.

Lu B, Li D, Zhang R, Shuai L, Schulze B, Kroth PG, Wang G*. Defense responses in female gametophytes of Saccharina japonica (Phaeophyta) induced by flg22-derived peptides. J. Appl. Phycol., 2016, 28: 1793-1801.

Wang S, Wang G (co-first authors), Weinberger F, Bian D, Nakaoka M, Lenz M. Anti-epiphyte defences in the red seaweed Gracilaria vermiculophylla: non-native algae are better defended than their native conspecifics. Journal of Ecology, 2016, 105: 445-457.

Wang G, Kroth P. Phycology in China (special issue), Algological Studies, Schweizerbart Science Publishers, 2014.


 

 


其他

山东高校优秀科研成果(自然科学类)三等奖1项、北京市科学技术三等奖1项、授权专利2项。