吕志一 博士，副教授，博士生导师
E-mail: lvzhiyi@ouc.edu.cn
教育及科研工作背景：
2002年-2006年，西北农林科技大学，生物科学。本科；
2007年-2010年，西北农林科技大学，发育生物学，硕士；
2010年-2014年，德国哥廷根大学，发育生物学，博士；
2014年-2019年，德国哥廷根大学医学中心从事博士后研究。
2019年-，中国海洋大学形态发生与进化实验室（董波教授团队）。
主要研究方向及成果：
从事胚胎发育过程中细胞间相互协调的分子生物学与生物物理学机制。利用果蝇和海鞘为实验模型，通过分子遗传学、生物化学、显微成像和定量分析等手段，研究细胞骨架、细胞连接在胚胎发育过程中的动态变化及其调控过程。研究结果相继发表在Journal of cell science、Development、Biophysical Journal、Angewandte Chemie、EMBO Rep等国际主流期刊。
Asso. Prof. Zhiyi LV:
Education:
2002.09 - 2006.07 Bachelor. in Biology, Northwest A&F University, China.
2007.09 - 2010.07 Master in Developmental biology, Northwest A&F University, China.
2010.10 – 2014.10 Doctoral study in Gene and Development project. Göttingen University, Germany.
2014.11 – 2019.10 Post-doc researcher with Jörg Großhans in Göttingen medical school. Germany.
Research focus:
Biochemical and biophysical mechanisms of cell coordination during embryonic development and morphogenesis. Using Drosophila and Ciona embryo as model systems, we are interested in how the cells form complex tissue architecture, especially in cell-cell communications via mechanical signal transduction. Currently, we are applying biochemical and molecular genetic approaches in combination with quantitative analysis and biophysical modeling to dissect the molecular mechanism of cell-cell communication during morphogenesis.
Publications:
Deqing Kong, Zhiyi Lv, Mattias Haering, Benjamin Lin, Fred Wolf, Jörg Großhans: In vivo optochemical control of cell contractility at signle cell resolution. EMBO Reports. In press.
Florian Mann, Zhiyi Lv, Jörg Grosshans, Felipe Opazo, Sebastian Kruss: Nanobody Conjugated Nanotubes for Targeted Near‐Infrared in vivo Imaging and Sensing. Angewandte Chemie 05/2019; 131(33)., DOI:10.1002/ange.201904167
Franz Kaiser, Zhiyi Lv, Daniel Marques Rodrigues, Jan Rosenbaum, Timo Aspelmeier, Jörg Großhans, Karen Alim: Mechanical Model of Nuclei Ordering in Drosophila Embryos Reveals Dilution of Stochastic Forces. Biophysical Journal 04/2018; 114(7):1730-1740., DOI:10.1016/j.bpj.2018.02.018
Zhiyi Lv, Jan Rosenbaum, Timo Aspelmeier, Jörg Großhans: A molecular guillotine reveals an interphase function of Kinesin-5. Journal of Cell Science 01/2018; 131(3)., DOI:10.1242/jcs.210583
Anja Schmidt*, Zhiyi Lv*, Jörg Großhans: ELMO and Sponge specify subapical restriction of Canoe and formation of the subapical domain in early Drosophila embryos. Development 12/2017; 145(2):dev.157909., DOI:10.1242/dev.157909
Zhiyi Lv, Jörg Großhans: A Radial Actin Network in Apical Constriction. Developmental Cell 11/2016; 39(3):280-282., DOI:10.1016/j.devcel.2016.10.017
Franziska Winkler, Maheshwar Gummalla, Lutz Künneke, Zhiyi Lv, Annette Zippelius, Timo Aspelmeier, Jörg Grosshans: Fluctuation Analysis of Centrosomes Reveals a Cortical Function of Kinesin-1. Biophysical Journal 09/2015; 109(5):856-68., DOI:10.1016/j.bpj.2015.07.044
Shuling Yan*, Zhiyi Lv*, Moritz Winterhoff*, Christian Wenzl, Thomas Zobel, Jan Faix, Sven Bogdan, Jörg Großhans: The F-BAR protein Cip4/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization. Journal of Cell Science 02/2013; 126(8)., DOI:10.1242/jcs.118422
