海洋资源生物学实验室

    海洋药用生物资源学实验室（Laboratory for Marine Medicinal Bioresources），围绕海洋药用生物物种多样性及其次级代谢产物多样性，开展基于海洋化学生态学作用的药用生物新资源发现与开拓研究，聚焦于中国南海珊瑚礁生态系统中药用生物资源，特别是在药用海洋低等无脊椎动物及其共附生微生物新资源的发现方面取得了重要进展。主要研究方向：基于新方法的海洋药用生物新资源发现；典型环境海洋药用生物化学生态学研究；海洋药用生物化学物质基础研究。

 王长云 教授

 E-mail: hangyun@ouc.edu.cn  

 Tel: 0532-82031536

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 刘志清 教授

 E-mail: liuzhiqing@ouc.edu.cn  

Tel: 0532-82031503

Resume

· Lu Liu, Zheng Zhang*, Chang-Lun Shao, Jin-Lan Wang, Hong Bai, Chang-Yun Wang*. Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains. Sci. Rep., 2015, 5(10463): 1−12.

· Dong-Lin Zhao, Chang-Lun Shao, Li-She Gan, Mei Wang, Chang-Yun Wang*. Chromone derivatives from a sponge-derived strain of the fungus Corynespora cassiicola. J. Nat. Prod., 2015, 78, 286−293.

· Xiao-Yan Qin, Kai-Lin Yang, Jing Li, Chang-Yun Wang*, Chang-Lun Shao*. Phylogenetic diversity and antibacterial activity of culturable fungi derived from the Zoanthid Palythoa haddoni in the South China Sea. Mar. Biotech., 2015, 17(1): 99-109

· Chang-Lun Shao*, Ru-Fang Xu, Chang-Yun Wang, Pei-Yuan Qian, Kai-Ling Wang, Mei-Yan Wei. Potent antifouling marine dihydroquinolin-2(1H)-one-containing alkaloids from the gorgonian coral-derived fungus Scopulariopsis sp.. Mar. Biotech., 2015, 17: 408–415.

·Fei Cao,^║ Ze-Hong Wu,^║ Chang-Lun Shao, Sen Pang, Xiao-Yan Liang, Nicole J. de Voogd, Chang-Yun Wang*. Cytotoxic scalarane sesterterpenoids from the South China Sea sponge Carteriospongia foliascens. Org. Biomol. Chem., 2015, 13, 4016−4024.

· Qing-Ai Liu, Chang-Lun Shao, Yu-Cheng Gu, Mathias Blum, Li-She Gan, Kai-Ling Wang, Min Chen, Chang-Yun Wang*. Antifouling and fungicidal resorcylic acid lactones from the sea anemone-derived fungus Cochliobolus lunatus.J. Agric. Food Chem., 2014, 62: 3183−3191.

· Fei Cao, Chang-Lun Shao, Min Chen, Meng-Qi Zhang, Kai-Xia Xu, Hong Meng,* Chang-Yun Wang*. Antiviral C-25 epimers of 26-acetoxy steroids from the South China Sea gorgonian Echinogorgia rebekka. J. Nat. Prod., 2014, 77, 1488−1493.

· Min Chen, Chang-Lun Shao, Xiu-Mei Fu, Chui-Jian Kong, Zhi-Gang She, Chang-Yun Wang*. Lumazine peptides penilumamides B–D and the cyclic pentapeptide asperpeptide A from a gorgonian-derived Aspergillus sp. fungus. J. Nat. Prod., 2014, 77: 1601–1606.

· Min Chen, Chang-Lun Shao, Hong Meng, Zhi-Gang She, Chang-Yun Wang*. Anti-respiratory syncytial virus prenylated dihydroquinolone derivatives from the gorgonian-derived fungus Aspergillus sp. XS-20090B15. J. Nat. Prod., 2014, 77, 2720−2724.

· Chang-Lun Shao, Ru-Fang Xu, Mei-Yan Wei, Zhigang She*, Chang-Yun Wang*. Structure and absolute configuration of fumiquinazoline L, an alkaloid from a gorgonian-derived Scopulariopsis sp. fungus. J. Nat. Prod., 2013, 76, 779−782.