董波 教授 博士生导师
海洋生物多样性与进化研究所副所长
山东省泰山学者特聘专家
中国海洋大学“筑峰人才工程”特聘教授
E-mail: bodong@ouc.edu.cn
Tel: 0532-82032732
https://www.researchgate.net/profile/Bo_Dong4
教育及工作背景：
1997年毕业于青岛海洋大学，2005年在中国科学院海洋研究所获博士学位，2006-2010年在挪威卑尔根大学萨斯国际海洋分子生物学中心做博士后， 2010-2014年受聘任日本理化学研究所神户发育生物学中心国际特别研究员。2014年至今任中国海洋大学“筑峰计划”特聘教授、青岛市创新创业领军人才、山东省“泰山学者”特聘教授、山东省有突出贡献中青年专家、入选国家万人计划科技创新领军人才。现任国际被囊动物学会学术指导委员会委员，《Marine Life Science & Technology》基础生物学领域主编，《Developmental Biology》编委，主持承担了国家科技部重点研发计划生物安全关键技术专项、政府间国际科技合作重点专项、山东省重大研发专项以及国家自然科学基金等多个项目。
主要研究方向及成果：
主要从事海洋动物遗传学与环境适应演化机制研究，以进化节点动物海鞘和模式动物果蝇为实验材料，通过遗传学、细胞发育生物学和生物物理学等多学科交叉途径开展研究。在入侵物种器官形态发生的遗传学基础、宿主环境适应性演化分子机制以及宿主与共生微生物协同演化机制等领域取得了重要进展，发现了脊索管腔形成的细胞学过程，解析了调控细胞及器官形态发生的重要信号通路，建立了生物管腔几何形状的数学物理模型，阐明了海鞘合子基因组激活调控机制以及海鞘入侵的基因组学遗传基础。研究成果以通讯作者身份发表在Science Advances，Nature Communications，PNAS、PLoS Biology、Current Biology，NAR、eLife、Cell Reports、SCLS、Development、MER等领域主流刊物发表论文140 余篇，他引3000次。多篇文章被选为期刊亮点、期刊点评及Faculty of 1000专家推荐。
实验室目前有硕士、博士及博士后位置开放，并欢迎客座研究科学家交流合作。如果您对实验室研究领域和方向感兴趣，并具有发育生物学、细胞生物学或生物物理学等背景，欢迎来信询问。
Prof. Dr. Bo DONG:
2014.9-: Professor, Ocean University of China, Qingdao, China;
2013.11- 2014. 9: Research Scientist, RIKEN Center for Developmental Biology (CDB), Kobe, Japan;
2010.11- 2013.10: Foreign Postdoctoral Researcher, RIKEN CDB;
2006.10- 2010.10: Postdoctoral fellow, Sars International Centre for Marine Molecular Biology, Bergen, Norway;
2001.7- 2005.7: Ph.D., Institute of Oceanology, Chinese Academy of Sciences (IOCAS), Qingdao, China.
Research Interests:
Our group is principally interested in uncovering cellular processes and the underlying mechanisms that support the biological tube formation. We use marine animal (Ciona) notochord andDrosophila tracheal system as models to understand the morphogenetic signaling network on polarized vesicle trafficking, cytoskeletal organization, membrane biogenesis and extracellular matrix dynamics during lumen formation and cell shape change.
Job and Contact:
We are always looking for people with experience and interests in developmental biology, Cell biology or biophysics to join us. If you are interested in working with us as a graduate student, postdoc or visiting scientist, please contacts us for possible openings.
Laboratory for Molecular Mechanisms and Cellular Biophysics of Organogenesis
Institute of Evolution & Marine Biodiversity, Ocean University of China
No.5 Yushan Road, 266003, Qingdao, China
Tel: 0532-82032732
E-mail:bodong@ouc.edu.cn
代表性文章（*通讯作者，#共同第一作者）
1. Jiang A.#, Han K.#, Wei J.#, Su X.#,Wang R., Zhang W., Liu X., Qiao J., Liu P., Liu Q., Zhang J. , Zhang N., Ge Y., Zhuang Y., Yu H., Wang S., Chen K., Xu X., Yang H, Fan G*, Dong B.*. Spatially-resolved single-cell atlas of ascidian endostyle provides insights into the origin of vertebrate pharyngeal organs. Science Advances, 2024, 10 (13), eadi9035.
2. Wei J.#, Zhang W.#, Jiang A#, Peng H.#, Zhang Q.#, Li Y., Bi J., Wang L., Liu P., Wang J., Ge Y., Zhang L., Yu H., Li L., Wang S., Leng L.*, Chen K.*, Dong B.* Spatiotemporal hierarchy and allele-specific expression of zygotic genome activation revealed by distant interspecific urochordate hybrids. Nature Communications, 2024, 15, 2395.
3. Peng H., Qiao J., Wang G., Shi W., Xia F., Qiao R., Dong B.* A collagen-rich arch in the urochordate notochord coordinates cell shaping and multi-tissue elongation. Current Biology, 2023, 33: 1-14.
4.Wei J.#, Liu, P.#, Liu F.#, Jiang A., Qiao J, Pu Z., Wang B., Zhang J., Jia D., Li Y.*, Wang S,* and Dong B*. EDomics: a comprehensive and comparative multiomics database for animal evo-devo. Nucleic Acids Research 2023, 51, D913–D923.
5.Liu A., Ouyang X., Wang Z., Dong B.* ELMOD3-Rab1A-Flotillin2 cascade regulates lumen formation via vesicle trafficking in Ciona notochord. Open Biology 2023, 13: 220367
6.Ouyang X. Wu B., Yu H., Dong B*. DYRK1-mediated phosphorylation of endocytic components is required for extracellular lumen expansion in ascidian notochord. Biological Research 2023, 56: 10.
7. Wang Z., Tan Z., Bi J., Liu A., Jiang A., Dong B*. Proteomic identification of intracellular vesicle trafficking and protein glycosylation requirements for lumen inflation in Ciona notochord. Proteomics 2023. e2200460.
8. Fu Y.#, Lv Z.#, Kong D., Fan Y., Dong B*, High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6. Cell proliferation. 2022, e13257. doi:10.1111/cpr.13257.
9. Sun X, Zhang X, Yang L, Dong B*, A microRNA cluster-Lefty pathway is required for cellulose synthesis during ascidian larval metamorphosis. Frontiers in Cell and Developmental Biology. 2022, 10:835906. doi: 10.3389/fcell.2022.835906.
10. Zhao L#, Gao F#, Gao S#, Liang Y#, Long H#, Lv Z#, Su Y#, Ye N#, Zhang L#, Zhao C#, Wang X, Song W*, Zhang S*, Dong B*, Biodiversity-based development and evolution: The emerging research systems in model and non-model organisms. Science China Life Sciences. 2021, 64(8):1236-1280. https://doi.org/10.1007/s11427-020-1915-y.
11. Peng H, Qiao R, Dong B*, Polarity establishment and maintenance in ascidian notochord. Frontiers in Cell and Developmental Biology. 2020, 8: 597446. doi: 10.3389/fcell.2020.597446.
12. Lu Q#, Gao Y#, Fu Y, Peng H, Shi W, Li B, Lv Z, Feng X, Dong B*, Ciona embryonic tail bending is driven by asymmetrical notochord contractility and coordinated by epithelial proliferation. Development. 2020. 147. doi:10.1242/dev.185868. (当期亮点文章，被选为最令人兴奋文章进行作者采访和推荐报道)
13. Bhattachan P., Rae J, Yu H, Jung W., Wei J.,Parton R. G., and Dong B*, Ascidian caveolin induces membrane curvature and protects tissue integrity and morphology during embryogenesis. The FASEB Journal, 2020, 34 (1): 1345-1361.
14. Lv Z, Lu Q, Dong B*, Morphogenesis: a focus on marine invertebrates. Marine Life Science & Technology, 2019, 1: 28-40.
15. Lu Q, Bhattachan P, Dong B*. Ascidian notochord elongation, Developmental Biology. 2019, 448：147-153.
16. Zhang X, Liu X, Liu C, Wei J, Yu H, Dong B*. Identification and characterization of microRNAs involved in ascidian larval metamorphosis. BMC Genomics. 2018, 19(1):168
17. Wei J, Wang G, Li X, Ren P, Yu H, Dong B*. 2017. Architectural delineation and molecular identification of extracellular matrix in ascidian embryos and larvae. Biology Open 6(9): 1383-1390. (封面文章)
18. 董波*。海洋模式动物海鞘及其脊索发育与调控。科学通报， 2015，60: 1167-1179.
19. Sehring I, Recho P, Denker E, Kourakis M, Mathiesen B, Hannezo E*, Dong B*, Jiang D*. 2015. Assembly and positioning of actomyosin rings by contractility and planar cell polarity.eLife 4: e09206. (当期亮点文章，faculty of 1000专家推荐)
20. Hannezo E#, *, Dong B#, *, Recho P, Joanny JF, Hayashi S. 2015. A cortical instability drives periodic supracellular actin pattern formation in epithelial tubes. PNAS 112 (28): 8620-8625. (PNAS同期配发了点评文章)
21. Dong B, Hayashi S. Shaping of biological tubes by mechanical interaction of cell and extracellular matrix. Current Opinion in Genetics & Development, 2015, 32: 129-134.(邀请综述文章)
22. Sehring I#,Dong B#,Denker E,Bhattachan P,Deng W, Mathiesen B, Jiang D. An equatorial contractile mechanism drives cell elongation but not cell division. PLoS Biology, 2014,12(2): e1001781. (同期配发了点评文章，faculty of 1000专家推荐)
23. Dong B*, Hannezo E, Hayashi S*. 2014. Balance between apical membrane growth and luminal matrix resistance determines the shape of epithelial tubule. Cell Reports 7(4): 941-950.
24. Dong B, Miao GX, Hayashi S. A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis in Drosophila. Development, 2014 141 (21): 4104-4109. (当期亮点文章)
25. DongB, KakiharaK, Otani T, WadaH, Hayashi S. 2013. Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control. Nature Communications 4, 1358.
26. Dong B, Deng W, Jiang D, Distinct cytoskeleton populations and extensive crosstalk control Ciona notochord tubulogenesis. Development, 2011, 138 (8): 1631-1641.(faculty of 1000专家推荐)
27.Dong B, Horie T, Denker E, Kusakabe T, Tsuda M, Smith WC, Jiang D. Tube formation by complex cellular processes in Ciona intestinalis notochord. Developmental Biology, 2009. 330: 237-249.
