张士璀 教授 博士生导师
E-mail: sczhang@ouc.edu.cn
Tel: 0532-82032787
简历：
张士璀，男，江苏泗阳人。中国海洋大学教授、博士生导师、国务院特殊津贴获得者、全国模范教师、山东省泰山学者、山东省有突出贡献专家、山东省优秀科技工作者并记二等功和青岛市劳模，海洋生物多样性与进化研究所副所长。国外学习和工作经历包括：加拿大多伦多大学博士后，美国Scripps海洋研究所高级访问学者，日本鹿儿岛大学JSPS Fellow和英国Essex大学高级访问学者。曾任海洋生命学院副院长、院长、教育部生物科学教学指导委员会成员、国际生物学联合会委员、山东省第十一届人大常委、山东省十一届政协常委；现任《Mar. Biotech.》和《J. Oceanol. Limnol.》等期刊编委、《Acta Oceanol. Sin.》期刊主编助理、山东省细胞生物学学会副理事长和山东省动物学学会副理事长。
主要学术成就：
主编《海洋生物技术和原理》和《海洋生物技术新进展》专著2部；主编《海洋生物学》教材1本，参编（副主编）《发育生物学》和《细胞工程学》教材2本；应邀参编英文专著《Reproductive Biology and Phylogeny of Fishes》、《Advances in Comparative Immunology》和《Oocytes Maternal Information and Functions》3本。已发表SCI收录论文200余篇。证明文昌鱼肝盲囊与脊椎动物肝脏具有同源性，发现文昌鱼存在类似脊椎动物的垂体-肝脏轴和垂体-甲状腺轴；首次报道肝脏特异性蛋白卵黄蛋白原和高磷蛋白具有免疫功能，被国外同行认为是“new findings”、“novel observations”和“novelties”。已获国家科技发明二等奖1项、山东省自然科学一等奖1项、教育部自然科学一等奖1项和国家海洋局海洋创新成果一等奖1项。
研究方向：
1、文昌鱼进化与发育生物学
2、鱼类发育与衰老生物学
主持的在研课题：
国家联合基金项目“免疫增强剂促进石斑鱼免疫分子和免疫力亲子传递之基础研究”，260万；2015-2018
国家基金面上项目“垂体-甲状腺轴起源探索：文昌鱼促甲状腺素β亚基及其受体的相互作用和功能鉴定”，63万；2018-2021
代表性论著目录：
主要论文（*通讯作者）:
1. Wang P, Liu S, Yang Q, Liu Z, *Zhang S. Functional characterization of thyrostimulin in amphioxus suggests an ancestral origin of the TH signaling pathway. Endocrinology. 2018 Sep 4. doi: 10.1210/en.2018-00550.
2. Li M, Gao Z, Ji D, *Zhang S. Functional Characterization of GH-Like Homolog in Amphioxus Reveals an Ancient Origin of GH/GH Receptor System.Endocrinology. 2014 Dec;155(12):4818-30. doi: 10.1210/en.2014-1377.
3. Liu S, Liu Y, Yang S, Huang Y, Qin Q, *Zhang S. Evolutionary conservation of molecular structure and antiviral function of a viral receptor, LGP2, in amphioxus Branchiostoma japonicum. European Journal of Immunolology. 2015 Dec;45(12):3404-16. doi: 10.1002/eji.201545860.
4. Gao Z, Li M, Ma J, *Zhang S. An amphioxus gC1q protein binds human IgG and initiates the classical pathway: Implications for a C1q-mediated complement system in the basal chordate. European Journal of Immunology. 2014 Dec;44(12):3680-95. doi: 10.1002/eji.201444734.
5. Wang S, *Zhang S, Zhao B, Lun L. Up-regulation of C/EBP by thyroid hormones: a case demonstrating the vertebrate-like thyroid hormone signaling pathway in amphioxus. Molecular & Cellular Endocrinology. 2009 Dec 10;313(1-2):57-63. doi: 10.1016/j.mce.2009.08.024.
6. Du X, Zhou Y, Song L, *Wang X, *Zhang S. Zinc finger protein 365 is a new maternal LPS-binding protein that defends zebrafish embryos against gram-negative bacterial infections. FASEB Journal. 2018 Feb;32(2):979-994. doi: 10.1096/fj.201700694R.
7. Wang X, Du X, *Li H, *Zhang S. Identification of the Zinc Finger Protein ZRANB2 as a Novel Maternal Lipopolysaccharide-binding Protein That Protects Embryos of Zebrafish against Gram-negative Bacterial Infections. Journal of Biological Chemistry. 2016 Feb 19;291(8):4019-34. doi: 10.1074/jbc.M115.679167.
8. Wang S, Wang Y, Ma J, Ding Y, *Zhang S. Phosvitin plays a critical role in the immunity of zebrafish embryos via acting as a pattern recognition receptor and an antimicrobial effector. Journal of Biological Chemistry. 2011 Jun 24;286(25):22653-64. doi: 10.1074/jbc.M111.247635.
9. Wang X, Chang Q, Wang Y, Su F, *Zhang S. Late-onset temperature reduction can retard the aging process in aged fish via a combined action of an antioxidant system and the insulin/insulin-like growth factor 1 signaling pathway. Rejuvenation Research. Dec;17(6):507-17. doi: 10.1089/rej.2014.1581.
10. Lu L, Yuan J, *Zhang S. Rejuvenating activity of salidroside (SDS): dietary intake of SDS enhances the immune response of aged rats.Age (Dordr). 2013 Jun;35(3):637-46. doi: 10.1007/s11357-012-9394-x.
英文专著：
1. Gao Zhanand *Zhang S. Cephalochordata: Branchiostoma. In “Advances in Comparative Immunology”(Ed. by Edwin L. Cooper), 2018. Springer. Pages 593-636.
2. Li Hand *Zhang S. Functions of Vitellogenin in Eggs. In “Oocytes Maternal Information and Functions” (Ed. by Malgorzata Kloc), 2017. Springer. Pages 389-401.
3. *Shicui Zhang, Haimanti Bhattacharya and Hongyan Li. Chapter 12 Embryogenesis and Development. In “Reproductive Biology and Phylogeny of Fishes (Agnathans and Bony fishes)” (Ed. by Barrie G.M. Jamieson), 2009. Science Publishers, Plymouth. Pages 485-517.
教材:
1、张士璀、何建国和孙世春主编《海洋生物学》；2018年第一版；中国海洋大学出版社，青岛。
2、张红卫（主编）、王子仁和张士璀（副主编）《发育生物学》；2001年第一版，2006年第二版，2013年第三版；高等教育出版社，北京。
Prof. Dr. Shicui ZHANG
Ph.D., Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China (1988); Vice-director, Institute of Evolution & Marine Biodiversity, OUC.
Professional activities:
Editorial board member of Mar. Biotecth., Acta Oceanol. Sin. and Chin. J. Oceanol. Limnol. Executive member of Chinese Society for Cell Biology (1999-2007; 2011-); Vice-president of Shandong Society for Cell Biology; Member of Advisory Committee for Education, Ministry of Education, China.
Honors and Awards:
Taishan Scholar Professor (2005; Shandong province government); First prize of the Natural Science Award of Shandong province (2007, chief scientist, Shandong province government).
Research Interests:
Evolutionary developmental biology and comparative immunology of amphioxus. Over 160 papers have been published in peer-reviewed international journal and 2 books (as senior author) since 1997.
